Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | FABP6 | P51161 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9128299 | 0.98 | LMNA (0.71) | LMNAMAPTHTTTP53MEN1 | |
| SCHEMBL9128979 | 0.94 | LMNA (0.73) | LMNAMAPTHTTTP53MEN1 | |
| SCHEMBL9124586 | 0.87 | LMNA (0.68) | LMNAMAPTHTTTP53MEN1 | |
| SCHEMBL4185454 | 0.84 | LMNA (0.64) | LMNAMAPTHTTTP53MEN1 | |
| SCHEMBL8088089 | 0.83 | LMNA (0.71) | LMNAMAPTHTTTP53MEN1 | |
| SCHEMBL9037446 | 0.82 | LMNA (0.76) | LMNAMAPTHTTTP53MEN1 | |
| SCHEMBL19911300 | 0.82 | LMNA (1.00) | LMNAMAPTHTTTP53MEN1 | |
| SCHEMBL13668113 | 0.82 | LMNA (0.66) | LMNAMAPTHTTTP53MEN1 | |
| SCHEMBL15779866 | 0.78 | LMNA (0.81) | LMNAMAPTHTTTP53MEN1 | |
| SCHEMBL30199049 | 0.77 | LMNA (0.68) | LMNAMAPTHTTTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405839-A | Vitamin B12 antagonist; inhibits cell growth; anticancer agents | TEIJIN LIMITED (JP) | 1995-04-11 | — | — | US | disclosed |
| EP-0425680-A1 | NEW VITAMIN B 12? DERIVATIVE, PRODUCTION THEREOF, AND APPLICATION THEREOF | TEIJIN LIMITED (JP) | 1991-05-08 | — | — | EP | disclosed |