Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
| ▸ | FABP6 | P51161 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1524043 | 0.91 | LMNA (0.68) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL19911300 | 0.86 | LMNA (1.00) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL9128979 | 0.85 | LMNA (0.73) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL19911323 | 0.84 | POLB (0.69) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL9128299 | 0.83 | LMNA (0.71) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL8088089 | 0.83 | LMNA (0.71) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL15779866 | 0.82 | LMNA (0.81) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL9123166 | 0.82 | LMNA (0.69) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL29097793 | 0.81 | LMNA (0.68) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL9040262 | 0.81 | PRPS1 (0.52) | LMNAMEN1KMT2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393574-B1 | Hexitol derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-01-31 | — | — | EP | disclosed |
| US-5053408-A | Cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0393574-A2 | Hexitol derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-10-24 | — | — | EP | disclosed |