Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9126112 | 1.00 | KDM4E (0.40) | KDM4EHTTKMT2AMEN1GAA | |
| SCHEMBL9121746 | 0.84 | FOXM1 (0.52) | KDM4EKMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL9124466 | 0.80 | KMT2A (0.54) | KDM4EHTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL9523527 | 0.80 | MEN1 (0.36) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9126148 | 0.80 | KMT2A (0.46) | KDM4EHTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL9124881 | 0.79 | PABPC1 (0.48) | KDM4EHTTKMT2AMEN1GAA | |
| SCHEMBL9520874 | 0.76 | KMT2A (0.50) | KDM4EKMT2AMEN1GAATDP1 | |
| SCHEMBL9125178 | 0.75 | NPC1 (0.37) | KDM4EKMT2AMEN1LMNA | |
| SCHEMBL10818564 | 0.72 | KMT2A (0.48) | KDM4EHTTKMT2AMEN1GAA | |
| SCHEMBL9125185 | 0.71 | MEN1 (0.38) | KMT2AMEN1TDP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5413997-A | For treatment of osteoporosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-05-09 | — | — | US | disclosed |
| EP-0395093-B1 | TRIPHENYLMETHANE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |
| US-5112867-A | Osteoporosis Treatment | KYOWA HAKKO GOGYO CO., LTD. (JP) | 1992-05-12 | — | — | US | disclosed |
| EP-0395093-A1 | Triphenylmethane derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-10-31 | — | — | EP | disclosed |