Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121818 | 0.79 | LMNA (0.51) | RAB9ASLC6A3LMNAHIF1ASLC6A2 | |
| SCHEMBL9123812 | 0.79 | ALDH1A1 (0.36) | NPC1RAB9ANR3C1PGRNR3C2 | |
| SCHEMBL9520874 | 0.79 | KMT2A (0.50) | RAB9ANR3C1PGRNR3C2AR | |
| SCHEMBL5936693 | 0.76 | KMT2A (0.38) | NPC1RAB9ASLC6A3LMNAOPRK1 | |
| SCHEMBL9124733 | 0.75 | ALDH1A1 (0.38) | NR3C1PGRNR3C2ARFFAR1 | |
| SCHEMBL9121903 | 0.75 | ALDH1A1 (0.41) | NPC1RAB9ATP53FFAR1KDM4E | |
| SCHEMBL9126112 | 0.75 | KDM4E (0.40) | KDM4ELMNAMEN1KMT2A | |
| SCHEMBL9123842 | 0.75 | KDM4E (0.40) | KDM4ELMNAMEN1KMT2A | |
| SCHEMBL917138 | 0.74 | TDP1 (0.51) | PGRARSLC6A3KDM4ELMNA | |
| SCHEMBL30335104 | 0.74 | TDP1 (0.51) | PGRARSLC6A3KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5413997-A | For treatment of osteoporosis | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-05-09 | — | — | US | disclosed |
| EP-0395093-B1 | TRIPHENYLMETHANE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |
| US-5112867-A | Osteoporosis Treatment | KYOWA HAKKO GOGYO CO., LTD. (JP) | 1992-05-12 | — | — | US | disclosed |
| EP-0395093-A1 | Triphenylmethane derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-10-31 | — | — | EP | disclosed |