Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | ME2 | P23368 | 1/20 | 0.57 |
| ▸ | ME1 | P48163 | 1/20 | 0.57 |
| ▸ | ME3 | Q16798 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902638 | 0.84 | GRM5 (1.00) | GRM5MAPTNPSR1LMNAALDH1A1 | |
| SCHEMBL6388426 | 0.82 | MAPT (0.70) | GRM5MAPTNPSR1LMNAALDH1A1 | |
| SCHEMBL6283959 | 0.81 | GRM5 (0.67) | GRM5MAPTNPSR1LMNAALDH1A1 | |
| SCHEMBL9122242 | 0.80 | — | — | |
| SCHEMBL8210319 | 0.80 | MAPT (0.76) | MAPTNPSR1LMNAALDH1A1ME2 | |
| SCHEMBL9123464 | 0.79 | LMNA (0.60) | GRM5LMNAALDH1A1KDM4EHTT | |
| SCHEMBL30528252 | 0.79 | MAPT (0.86) | MAPTNPSR1LMNAALDH1A1ME2 | |
| SCHEMBL7840682 | 0.77 | MAPT (0.72) | GRM5MAPTNPSR1LMNAALDH1A1 | |
| SCHEMBL3299369 | 0.76 | MAPT (0.70) | GRM5MAPTNPSR1LMNAALDH1A1 | |
| SCHEMBL8245954 | 0.76 | MAPT (0.70) | GRM5MAPTNPSR1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476848-A | Antihistamines | SANKYO COMPANY, LIMITED (JP) | 1995-12-19 | — | — | US | disclosed |
| US-5461051-A | Tetracyclic compounds having anti-allergic and anti-asthmatic activities and their use | SANKYO COMPANY, LIMITED (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5362725-A | Antiallergens, antiasthmatic | SANKYO COMPANY, LIMITED (JP) | 1994-11-08 | — | — | US | disclosed |
| EP-0505014-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1992-09-23 | — | — | EP | disclosed |
| EP-0421823-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1991-04-10 | — | — | EP | disclosed |