Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzimidazole SCHEMBL4295899 | 0.81 | PRKCI (0.46) | PARP1MMP12SMN1; SMN2ALDH1A1HPGD | |
| Benzimidazole SCHEMBL2971795 | 0.79 | SMN1; SMN2 (0.48) | PARP1MMP12SMN1; SMN2ALDH1A1HPGD | |
| Benzimidazole SCHEMBL2950245 | 0.79 | SMN1; SMN2 (0.48) | PARP1MMP12SMN1; SMN2ALDH1A1HPGD | |
| Benzimidazole SCHEMBL1293052 | 0.79 | SMN1; SMN2 (0.48) | PARP1MMP12SMN1; SMN2ALDH1A1HPGD | |
| Benzimidazole SCHEMBL834184 | 0.79 | ESR2 (0.45) | TSHRLRRK2USP2MAPK1ALDH1A1 | |
| Benzimidazole SCHEMBL14722521 | 0.78 | SMN1; SMN2 (0.41) | PARP1MMP12SMN1; SMN2ALDH1A1HPGD | |
| Benzimidazole SCHEMBL14722520 | 0.78 | SMN1; SMN2 (0.41) | PARP1MMP12SMN1; SMN2ALDH1A1HPGD | |
| Benzimidazole SCHEMBL7773385 | 0.77 | KDM4E (0.50) | PARP1MMP12SMN1; SMN2ALDH1A1HPGD | |
| Benzimidazole SCHEMBL10432218 | 0.77 | KDM4E (0.50) | PARP1MMP12SMN1; SMN2ALDH1A1HPGD | |
| Benzimidazole SCHEMBL4441683 | 0.77 | SMN1; SMN2 (0.47) | PARP1MMP12SMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470867-A | Imidazoles and their salts having antagonistic activity to angiotesin II recetors | ROUSSEL-UCLAF (FR) | 1995-11-28 | — | — | US | disclosed |
| US-5338756-A | Angiotensin II receptor antagonists | ROUSSEL UCLAF (FR) | 1994-08-16 | — | — | US | disclosed |
| EP-0461040-A1 | Imidazol derivatives, their process for production, intermediates, their application as medicaments and the pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1991-12-11 | — | — | EP | disclosed |