Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Benzimidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | QPCT | Q16769 | 2/20 | 0.46 |
| ▸ | QPCTL | Q9NXS2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzimidazole SCHEMBL2971795 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL1293052 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL17786061 | 0.98 | KDM4E (0.50) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL29373085 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL29406970 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL7773385 | 0.98 | KDM4E (0.50) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL10432218 | 0.98 | KDM4E (0.50) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL4441683 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL11293000 | 0.98 | KDM4E (0.50) | SMN1; SMN2PDPK1CA12PARP1ALOX15 | |
| Benzimidazole SCHEMBL31239694 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2PDPK1CA12PARP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103193728-A | Synthesis process of chiral ionic liquid with (R)-thiazolidinyl-2-thione-4-carboxylic acid as negative ion | UNIV XIN JIANG | 2013-07-10 | — | — | CN | claimed |
| EP-1421076-A1 | HYDRATES OF OPTIONALLY SUBSTITUTED 2-(2-PYRIDINYL)METHYLTHIO-1H-BENZIMIDAZOLES AND METHOD FOR THE PRODUCTION THEREOF | Grünenthal GmbH (DE) | 2004-05-26 | — | — | EP | claimed |
| WO-2003016301-A1 | HYDRATES OF OPTIONALLY SUBSTITUTED 2-(2-PYRIDINYL)METHYLTHIO-1H-BENZIMIDAZOLES AND METHOD FOR THE PRODUCTION THEREOF | Grünenthal GmbH (DE) | 2003-02-27 | — | — | WO | claimed |
| EP-4644489-A1 | WATER-ABSORBING RESIN COMPOSITION, WATER-STOPPING MATERIAL, AND CABLE | Sumitomo Seika Chemicals Co., Ltd. (JP) | 2025-11-05 | — | — | EP | disclosed |
| WO-2023027236-A1 | MICELLE COMPRISING BENZIMIDAZOLE-CARBOHYDRATE CONJUGATE COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF AS ANTICANCER AGENT OR ANTIVIRAL AGENT | (주)바이오메트릭스 테크놀로지 | 2023-03-02 | — | — | WO | disclosed |
| CN-108473441-B | Poly (phenylene) and m-terphenyl as protecting group for benzimidazolium hydroxide | 西蒙弗雷泽大学 | 2021-12-21 | — | — | CN | disclosed |
| CN-108473441-B | Poly (phenylene) and m-terphenyl as protecting group for benzimidazolium hydroxide | 西蒙弗雷泽大学 | 2021-12-21 | — | — | CN | disclosed |
| CN-108473441-B | Poly (phenylene) and m-terphenyl as protecting group for benzimidazolium hydroxide | 西蒙弗雷泽大学 | 2021-12-21 | — | — | CN | disclosed |
| US-10800874-B2 | Poly(phenylene) and m-Terphenyl as protecting groups for benzimidazolium hydroxides | SIMON FRASER UNIVERSITY (CA) | 2020-10-13 | — | — | US | disclosed |
| US-10800874-B2 | Poly(phenylene) and m-Terphenyl as protecting groups for benzimidazolium hydroxides | SIMON FRASER UNIVERSITY (CA) | 2020-10-13 | — | — | US | disclosed |
| US-10800874-B2 | Poly(phenylene) and m-Terphenyl as protecting groups for benzimidazolium hydroxides | SIMON FRASER UNIVERSITY (CA) | 2020-10-13 | — | — | US | disclosed |
| WO-2010148314-A2 | PREPARATION OF ESOMEPRAZOLE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-12-23 | — | — | WO | disclosed |
| US-20100291670-A1 | Method for Detecting Candida on Skin | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2010-11-18 | — | — | US | disclosed |
| US-7763442-B2 | Method for detecting candida on skin | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2010-07-27 | — | — | US | disclosed |
| US-20080057532-A1 | Method for detecting Candida on skin | KIMBERLY-CLARK WORLDWIDE, INC. | 2008-03-06 | — | — | US | disclosed |
| CN-1288176-A | Tensile strength and durable fibrous photosensitive base materials | EASTMAN KODAK CO (US) | 2001-03-21 | — | — | CN | disclosed |
| CN-1284660-A | Flexible imaging element using microporous polyester piece | EASTMAN KODAK CO (US) | 2001-02-21 | — | — | CN | disclosed |
| EP-0091794-B1 | PROCESS FOR PREPARING 1.6-DISUBSTITUTED 2-AMINOBENZIMIDAZOLES | ELI LILLY AND COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| US-4434288-A | Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles | ELI LILLY AND COMPANY (US) | 1984-02-28 | — | — | US | disclosed |
| EP-0091794-A1 | Process for preparing 1.6-disubstituted 2-aminobenzimidazoles | ELI LILLY AND COMPANY (US) | 1983-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10800874-B2 | Poly(phenylene) and m-Terphenyl as protecting groups for benzimidazolium hydroxides | H1-4, PNMT, H1-0 | PARP1 386/4885SMN1; SMN2 1589/4885PDPK1 1388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.