Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PIKFYVE | Q9Y2I7 | 11/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912825 | 1.00 | KDM4E (0.49) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL912258 | 0.81 | POLB (0.41) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL912260 | 0.81 | POLB (0.41) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL912583 | 0.73 | ALDH1A1 (0.32) | MAPTLMNAALDH1A1 | |
| SCHEMBL912362 | 0.71 | KDM4E (0.70) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL913770 | 0.71 | KDM4E (0.59) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL912824 | 0.71 | KDM4E (0.59) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL912360 | 0.71 | KDM4E (0.70) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL13144751 | 0.71 | PIKFYVE (0.76) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL913109 | 0.69 | KDM4E (0.72) | KDM4EMAPTLMNAHPGDPIKFYVE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872005-B2 | 2-substituted heteroaryl compounds | SYNTA PHARMACEUTICALS CORPORATION (US) | 2011-01-18 | — | — | US | disclosed |
| US-20060063739-A1 | 2-Substituted heteroaryl compounds | LSI FINANCING LLC, AS ADMINISTRATIVE AGENT | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063739-A1 | 2-Substituted heteroaryl compounds | IL2, IL4, IL2RA | KDM4E 4142/4885MAPT 1171/4885LMNA 4190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.