Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272585 | 0.92 | REN (0.47) | RENTSHRHTR1ASLC6A4KMT2A | |
| SCHEMBL8263807 | 0.85 | REN (0.60) | RENTSHRHTR1ASLC6A4KMT2A | |
| SCHEMBL5710197 | 0.85 | REN (0.54) | RENTSHRHTR1ASLC6A4KMT2A | |
| SCHEMBL1083640 | 0.85 | REN (0.54) | RENTSHRHTR1ASLC6A4KMT2A | |
| SCHEMBL8285802 | 0.84 | REN (0.53) | RENTSHRHTR1ASLC6A4KMT2A | |
| SCHEMBL16897915 | 0.83 | MAPT (0.42) | RENTSHRHTR1ASLC6A4KMT2A | |
| SCHEMBL78416 | 0.83 | REN (0.53) | RENTSHRHTR1ASLC6A4KMT2A | |
| SCHEMBL7992571 | 0.83 | REN (0.53) | RENTSHRHTR1ASLC6A4KMT2A | |
| SCHEMBL21940988 | 0.82 | REN (0.40) | RENTSHRHTR1ASLC6A4KMT2A | |
| SCHEMBL8282811 | 0.82 | HTR1A (0.60) | RENTSHRHTR1ASLC6A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| EP-2163245-A1 | Renin inhibitors for the treatment of psoriasis | Novartis Ag (CH) | 2010-03-17 | — | — | EP | disclosed |