Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 4/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669574 | 0.75 | MAPT (0.40) | MAOAMAOB | |
| SCHEMBL6839168 | 0.72 | CYP1A2 (0.39) | — | |
| SCHEMBL10200201 | 0.71 | ALOX5 (0.53) | SLC6A2MAOAMAOBSLC6A3 | |
| SCHEMBL8221790 | 0.70 | PARP15 (0.50) | PARP15PARP10SLC6A2SLC6A4HTR3A | |
| SCHEMBL3718507 | 0.69 | TLR4 (0.49) | TLR4TLR2 | |
| SCHEMBL12647108 | 0.69 | TLR4 (0.49) | TLR4TLR2 | |
| SCHEMBL12247660 | 0.69 | MAOA (0.46) | PARP15PARP10SLC6A2SLC6A4HTR3A | |
| SCHEMBL15776314 | 0.69 | BRD4 (0.37) | BRD4 | |
| SCHEMBL29024848 | 0.68 | PARP15 (0.64) | PARP15PARP10PARP2TDP1 | |
| SCHEMBL8930160 | 0.67 | PARP15 (0.55) | PARP15PARP10PARP2KDM1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449940-B1 | NEW THERAPEUTICALLY ACTIVE COMPOUND AND A PROCESS FOR ITS PREPARATION | HAESSLE AB (SE) | 1995-09-13 | — | — | EP | claimed |
| US-5039808-A | Chemical intermediate for antisecretory agent | AKTIEBOLAGET HASSLE (SE) | 1991-08-13 | — | — | US | claimed |
| WO-1990006925-A1 | NEW THERAPEUTICALLY ACTIVE COMPOUND AND A PROCESS FOR ITS PREPARATION | Aktiebolaget Hässle (SE) | 1990-06-28 | — | — | WO | claimed |
| EP-0449940-B1 | NEW THERAPEUTICALLY ACTIVE COMPOUND AND A PROCESS FOR ITS PREPARATION | HAESSLE AB (SE) | 1995-09-13 | — | — | EP | disclosed |
| US-5441968-A | Therapeutically active fluoro substituted benzimidazoles | AKTIEBOLAGET HASSLE (SE) | 1995-08-15 | — | — | US | disclosed |
| US-5274099-A | A mixture of 5- and 6-fluoro-2-(((4-cyclopropylmethoxy-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole-1-yl methyl ethyl carbonate | AKTIEBOLAGET HASSLE (SE) | 1993-12-28 | — | — | US | disclosed |
| EP-0506759-A1 | THERAPEUTICALLY ACTIVE FLUORO SUBSTITUTED BENZIMIDAZOLES, PROCESSES FOR THEIR PREPARATION AS WELL AS THEIR USE | AKTIEBOLAGET HÄSSLE (SE) | 1992-10-07 | — | — | EP | disclosed |
| US-5049674-A | Antiulcer | AKTIEBOLAGET HASSLE (SE) | 1991-09-17 | — | — | US | disclosed |
| US-5039808-A | Chemical intermediate for antisecretory agent | AKTIEBOLAGET HASSLE (SE) | 1991-08-13 | — | — | US | disclosed |
| WO-1991009028-A1 | THERAPEUTICALLY ACTIVE FLUORO SUBSTITUTED BENZIMIDAZOLES, PROCESSES FOR THEIR PREPARATION AS WELL AS THEIR USE | Aktiebolaget Hässle (SE) | 1991-06-27 | — | — | WO | disclosed |
| US-5008278-A | 5-fluoro-2 (4-cyclopropylmethoxy-2-pridinyl)-methyl! sulfinyl!-1h-benzimidazole for inhibiting gastric acid secretion | AKTIEBOLAGET HASSLE (SE) | 1991-04-16 | — | — | US | disclosed |
| WO-1990006925-A1 | NEW THERAPEUTICALLY ACTIVE COMPOUND AND A PROCESS FOR ITS PREPARATION | Aktiebolaget Hässle (SE) | 1990-06-28 | — | — | WO | disclosed |