Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR7 | P34969 | 5/20 | 0.40 |
| ▸ | HTR6 | P50406 | 5/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9130462 | 0.92 | DRD2 (0.50) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9470558 | 0.87 | HTR1A (0.39) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9132222 | 0.87 | HTR1A (0.40) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9471211 | 0.85 | CHRM2 (0.43) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9130018 | 0.84 | DRD2 (0.46) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9134861 | 0.83 | DRD2 (0.48) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9132087 | 0.82 | HTR1A (0.46) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9134839 | 0.82 | ADRA1D (0.42) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9132145 | 0.81 | HTR1A (0.42) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9132047 | 0.81 | HTR1A (0.42) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5453437-A | 1,3-disubstituted pyrrolidines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-09-26 | — | — | US | disclosed |
| US-5037841-A | For treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-08-06 | — | — | US | disclosed |