Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641403 | 0.88 | SIGMAR1 (0.45) | AOC3TSHRALDH1A1SIGMAR1BCHE | |
| SCHEMBL3203375 | 0.84 | AOC3 (0.48) | AOC3TSHRALDH1A1TP53SLC6A2 | |
| SCHEMBL3061994 | 0.83 | SLC6A2 (0.50) | AOC3TSHRALDH1A1SLC6A2TAAR1 | |
| SCHEMBL5312674 | 0.81 | ALDH1A1 (0.43) | AOC3TSHRALDH1A1SIGMAR1BCHE | |
| SCHEMBL18079510 | 0.78 | BCHE (0.51) | AOC3TSHRALDH1A1TP53SLC6A2 | |
| SCHEMBL27842333 | 0.78 | EPHX1 (0.54) | AOC3TSHRALDH1A1SLC6A2TAAR1 | |
| SCHEMBL18510053 | 0.78 | TAS1R3 (0.40) | ALDH1A1 | |
| SCHEMBL16390836 | 0.78 | CSNK1E (0.48) | AOC3TSHRALDH1A1SIGMAR1CSNK1E | |
| SCHEMBL7050937 | 0.77 | TSHR (0.48) | AOC3TSHRALDH1A1TP53SLC6A2 | |
| SCHEMBL8108561 | 0.77 | TSHR (0.43) | AOC3TSHRALDH1A1TP53SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5422355-A | Also for treating memory impairment, dementia or cerebral insufficiency | JOHN WYETH & BROTHER, LIMITED (GB) | 1995-06-06 | — | — | US | disclosed |
| EP-0407032-B1 | Aromatic and heteroaromatic amines for treating depressions, cerebral insufficiency disorders or dementia | WYETH JOHN & BROTHER LTD (GB) | 1994-11-09 | — | — | EP | disclosed |
| US-5260331-A | Selective gamma aminobutyric acid autoreceptors; treatment of dementia | JOHN WYETH & BROTHER LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| US-5086073-A | Brain disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1992-02-04 | — | — | US | disclosed |
| EP-0407032-A2 | Aromatic and heteroaromatic amines for treating depressions, cerebral insufficiency disorders or dementia | JOHN WYETH & BROTHER LIMITED (GB) | 1991-01-09 | — | — | EP | disclosed |