Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9129953 | 0.94 | HTR1A (0.52) | HTR1ADRD2RAB9ANPC1PAX8 | |
| SCHEMBL9129907 | 0.94 | HTR1A (0.50) | HTR1ADRD2RAB9ANPC1PAX8 | |
| SCHEMBL9131046 | 0.93 | HTR1A (0.54) | HTR1ADRD2HTR2AHTR7ADRA1D | |
| SCHEMBL9130484 | 0.91 | HTR1A (0.46) | HTR1ADRD2PKMHTR2AHTR7 | |
| SCHEMBL9131958 | 0.90 | HTR1A (0.56) | HTR1ADRD2RAB9ANPC1PAX8 | |
| SCHEMBL9131814 | 0.89 | HTR1A (0.47) | HTR1ADRD2RAB9ANPC1HTR2A | |
| SCHEMBL9130405 | 0.87 | HTR2A (0.38) | MAPTHTR2AHTR7CHRM2CHRM3 | |
| SCHEMBL9129942 | 0.85 | HTR1A (0.53) | HTR1ADRD2PKMHTR2AHTR7 | |
| SCHEMBL9131296 | 0.85 | HTR1A (0.51) | HTR1ADRD2PKMHTR2AHTR7 | |
| SCHEMBL9131001 | 0.85 | HTR1A (0.54) | HTR1ADRD2HTR2AHTR7ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5453437-A | 1,3-disubstituted pyrrolidines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-09-26 | — | — | US | disclosed |
| US-5274097-A | A 1-N-heterocyclic alkylene-3-carbo or heterocyclic ring oxypyrrolidine derivative | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| US-5037841-A | For treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-08-06 | — | — | US | disclosed |