Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR7 | P34969 | 4/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | USP8 | P40818 | 1/20 | 0.37 |
| ▸ | OTUB1 | Q96FW1 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9134839 | 0.94 | ADRA1D (0.42) | HTR2AHTR7CHRM2CHRM3 | |
| SCHEMBL9131313 | 0.94 | HTR1A (0.42) | HTR2AHTR7CHRM2CHRM3 | |
| SCHEMBL9132145 | 0.93 | HTR1A (0.42) | HTR2AHTR7CHRM2CHRM3 | |
| SCHEMBL9130400 | 0.90 | HPGD (0.45) | — | |
| SCHEMBL9131963 | 0.87 | HTR1A (0.45) | HTR2AHTR7CHRM2CHRM3MAPT | |
| SCHEMBL9130484 | 0.86 | HTR1A (0.46) | HTR2AHTR7SMN1; SMN2 | |
| SCHEMBL9132000 | 0.84 | DRD2 (0.41) | HTR2AHTR7 | |
| SCHEMBL9131309 | 0.84 | HTR1A (0.51) | HTR2AHTR7 | |
| SCHEMBL9134836 | 0.84 | DRD2 (0.52) | HTR2AHTR7 | |
| SCHEMBL9132141 | 0.83 | DRD2 (0.53) | HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5453437-A | 1,3-disubstituted pyrrolidines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-09-26 | — | — | US | disclosed |
| US-5274097-A | A 1-N-heterocyclic alkylene-3-carbo or heterocyclic ring oxypyrrolidine derivative | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| US-5037841-A | For treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-08-06 | — | — | US | disclosed |