Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 10/20 | 0.67 |
| ▸ | HTR1A | P08908 | 5/20 | 0.57 |
| ▸ | DRD2 | P14416 | 5/20 | 0.57 |
| ▸ | HTR2A | P28223 | 5/20 | 0.57 |
| ▸ | HTR6 | P50406 | 5/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132055 | 0.98 | HTR7 (0.65) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9131080 | 0.94 | HTR7 (0.59) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9131045 | 0.90 | HTR7 (0.58) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9132091 | 0.89 | HTR7 (0.52) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9134164 | 0.88 | HTR7 (0.55) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9132049 | 0.87 | HTR7 (0.50) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9131864 | 0.87 | DRD2 (0.55) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9669919 | 0.84 | HTR7 (0.55) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9131067 | 0.84 | HTR7 (0.50) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL9131075 | 0.83 | HTR7 (0.45) | HTR7HTR1ADRD2HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5453437-A | 1,3-disubstituted pyrrolidines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-09-26 | — | — | US | disclosed |
| US-5274097-A | A 1-N-heterocyclic alkylene-3-carbo or heterocyclic ring oxypyrrolidine derivative | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| EP-0338331-B1 | 1,3 DISUBSTITUTED PYRROLIDINES | BAYER AG (DE) | 1992-10-21 | — | — | EP | disclosed |
| US-5037841-A | For treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-08-06 | — | — | US | disclosed |
| EP-0338331-A1 | 1,3 Disubstituted Pyrrolidines | BAYER AG (DE) | 1989-10-25 | — | — | EP | disclosed |