Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.58 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL59690 | 0.95 | CA4 (0.64) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL3397279 | 0.95 | CA4 (0.50) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL28265468 | 0.95 | CA4 (0.50) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL6704237 | 0.95 | CA4 (0.64) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL28537604 | 0.91 | CA4 (0.58) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL5309573 | 0.91 | CA4 (0.58) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL28890785 | 0.91 | CA4 (0.58) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL9442722 | 0.91 | CA4 (0.58) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL9221146 | 0.91 | CA4 (0.46) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL7752847 | 0.91 | CA4 (0.58) | CA4FAHD1MEN1LDHABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140209467-A1 | Method For Producing White Anodized Aluminum Oxide | NANO AND ADVANCED MATERIALS INSTITUTE LIMITED (HK) | 2014-07-31 | — | — | US | disclosed |
| WO-2012119306-A1 | Method for Producing White Anodized Aluminum Oxide | NANO AND ADVANCED MATERIALS INSTITUTE LIMITED (CN) | 2012-09-13 | — | — | WO | disclosed |
| US-5391787-A | Preparing a C14-C22 fatty acid alkaline earth metal salt product free of fatty acids and glycerides; hydrolysis; salt formation; cattle feed additive | CHURCH & DWIGHT CO., INC. (US) | 1995-02-21 | — | — | US | disclosed |
| WO-1994025421-A1 | PROCESS FOR PRODUCTION OF HIGH PURITY FATTY ACID SALT PRODUCTS | CHURCH & DWIGHT COMPANY, INC. (US) | 1994-11-10 | — | — | WO | disclosed |