Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.64 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6704237 | 1.00 | CA4 (0.64) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL5309573 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL28890785 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL9442722 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL7752847 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL28537604 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL9133995 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL18042414 | 0.95 | CA1 (0.56) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL2970314 | 0.95 | CA1 (0.56) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL11309619 | 0.95 | CA1 (0.56) | CA4FAHD1CA1CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 216 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4387955-A1 | SYNTHESIS OF BRIVARACETAM | OPTIMUS DRUGS PRIVATE LIMITED (IN) | 2024-06-26 | — | — | EP | claimed |
| CN-117043141-A | 7-nitro-8-hydroxyquinoline derivative, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2023-11-10 | — | — | CN | claimed |
| WO-2023076589-A1 | PRETREATMENT OF LIGNOCELLULOSE USING TWO STAGE ALKALI AND MECHANICAL REFINING PROCESSES | ALLIANCE FOR SUSTAINABLE ENERGY, LLC (US) | 2023-05-04 | — | — | WO | claimed |
| WO-2023021363-A1 | SYNTHESIS OF BRIVARACETAM | OPTIMUS DRUGS PRIVATE LIMITED (IN) | 2023-02-23 | — | — | WO | claimed |
| EP-3775374-B1 | WRAPPING PAPER WITH USE INDICATOR FOR AEROSOL GENERATING ARTICLES | DELFORTGROUP AG (AT) | 2022-12-21 | — | — | EP | claimed |
| WO-2022253152-A1 | 7-NITRO-8-HYDROXYQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 江苏亚虹医药科技股份有限公司 | 2022-12-08 | — | — | WO | claimed |
| CN-115368412-A | Method for preparing minodronic acid | 扬子江药业集团北京海燕药业有限公司 | 2022-11-22 | — | — | CN | claimed |
| CN-214780790-U | Waste incineration fly ash recycling combination device | 上海东硕环保科技股份有限公司 | 2021-11-19 | — | — | CN | claimed |
| CN-112551557-A | Waste incineration fly ash recycling combination device and use method thereof | 上海东硕环保科技股份有限公司 | 2021-03-26 | — | — | CN | claimed |
| CN-111974386-A | Carbonyl sulfide hydrolysis catalyst and preparation method thereof | 济南环陶环保工程有限公司 | 2020-11-24 | — | — | CN | claimed |
| WO-2004074251-A1 | DERIVATIVES OF AZASUGARS AS ANTICANCER AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2004-09-02 | — | — | WO | claimed |
| US-20030125553-A1 | Process for the preparation of new antidiabetic agents | DR. REDDY'S LABORATORIES LIMITED | 2003-07-03 | — | — | US | claimed |
| US-6248919-B1 | E.G., (2S)-2-(((5-((BUTYL(2-CYCLOHEXYLETHYL)AMINO)METHYL) -2'-METHYL(1,1'-BIPHENYL)-2-YL)CARBONYL)AMINO)-4-(METHYLSULFAN YL)BUTANOIC ACID, OR A PHARMACEUTICALLY ACCEPTABLE SALT OR PRODRUG THEREOF. | ABBOTT LABORATORIES | 2001-06-19 | — | — | US | claimed |
| EP-1086140-A1 | MODIFIED GELLAN GUM COMPOSITION PROCESS FOR PREPARATION OF SAME AND USE THEREOF | Monsanto p.l.c. (GB) | 2001-03-28 | — | — | EP | claimed |
| US-6165505-A | Sterilant effervescent formulation | CHEM-LINK LABORATORIES, LLC (US) | 2000-12-26 | — | — | US | claimed |
| WO-1999064468-A1 | MODIFIED GELLAN GUM COMPOSITION PROCESS FOR PREPARATION OF SAME AND USE THEREOF | MONSANTO P.L.C. (GB) | 1999-12-16 | — | — | WO | claimed |
| US-5124237-A | Production of photopolymerized relief printing plates having a non-tacky surface | BASF AKTIENGESELLSCHAFT (DE) | 1992-06-23 | — | — | US | claimed |
| US-5118345-A | High strength; contains fired carbon black, graphite, water, alkali metal phosphates, borates and carbonates | J.S. STAEDTLER GMBH & CO. (DE) | 1992-06-02 | — | — | US | claimed |
| US-4883573-A | ULTRAFILTRATION, RECYCLING | BASF AKTIENGESELLSCHAFT (DE) | 1989-11-28 | — | — | US | claimed |
| US-4340253-A | Preflush-lixiviant process for solution mining of uranium ore beds | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (US) | 1982-07-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030125553-A1 | Process for the preparation of new antidiabetic agents | GLP1R, GPR119, SLC5A1 | CA4 1525/4885FAHD1 2046/4885CA1 3473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.