Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9136129 | 0.84 | ALOX5 (0.55) | ALOX5OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL1600273 | 0.75 | ALOX5 (0.55) | ALOX5OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL31734191 | 0.72 | OPRM1 (0.41) | ALOX5OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL30999316 | 0.72 | OPRM1 (0.41) | ALOX5OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL7809211 | 0.70 | OPRM1 (0.49) | ALOX5OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL9197051 | 0.70 | CHRNA1 (0.39) | ALOX5SLC6A4 | |
| SCHEMBL8553527 | 0.70 | CHRNA1 (0.39) | ALOX5SLC6A4 | |
| SCHEMBL7809125 | 0.69 | OPRM1 (0.48) | ALOX5OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL1625409 | 0.69 | OPRM1 (0.67) | OPRM1OPRD1OPRK1ALDH1A1SLC22A1 | |
| SCHEMBL9222744 | 0.68 | ALOX5 (0.37) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462830-B1 | Cyclic ether derivatives | ZENECA LTD (GB) | 1995-10-18 | — | — | EP | disclosed |
| US-5407945-A | Pyran derivatives and their use as inhibitors of 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES, INC. (GB) | 1995-04-18 | — | — | US | disclosed |
| US-5254581-A | Used in the treatment of various inflammatory and allergic diseases | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0462830-A2 | Cyclic ether derivatives | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |