Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tertatolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 7/20 | 0.64 |
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 0.64 |
| ▸ | HTR1A | P08908 | 12/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | DRD3 | P35462 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tertatolol SCHEMBL49635 | 0.85 | HTR1A (1.00) | HTR1AADRA2ASLC6A2SLC6A4ADRB2 | |
| Tertatolol SCHEMBL6513139 | 0.85 | HTR1A (1.00) | HTR1AADRA2ASLC6A2SLC6A4ADRB2 | |
| Tertatolol SCHEMBL49634 | 0.85 | HTR1A (1.00) | HTR1AADRA2ASLC6A2SLC6A4ADRB2 | |
| Tertatolol SCHEMBL23234262 | 0.84 | HTR1A (0.98) | HTR1AADRA2ASLC6A2SLC6A4ADRB2 | |
| Tertatolol SCHEMBL388069 | 0.84 | HTR1A (0.98) | HTR1AADRA2ASLC6A2SLC6A4ADRB2 | |
| Tertatolol SCHEMBL365413 | 0.84 | HTR1A (0.98) | HTR1AADRA2ASLC6A2SLC6A4ADRB2 | |
| Tertatolol SCHEMBL1649964 | 0.83 | HTR1A (0.96) | HTR1AADRA2ASLC6A2SLC6A4ADRB2 | |
| R-Nadolol SCHEMBL9276552 | 0.81 | ADRB2 (0.70) | HTR1AADRA2ASLC6A2ADRB2ADRB1 | |
| SCHEMBL6451228 | 0.81 | HTR1A (0.72) | HTR1AADRB2ADRB1CYP1A2ADRB3 | |
| Pindolol SCHEMBL5220 | 0.80 | HTR1A (1.00) | HTR1AADRA2ASLC6A2SLC6A4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5455269-A | Treatment of coronary insufficiency, arrhythmia | BALIGADOO SOORIANARAIN (MU) | 1995-10-03 | — | — | US | disclosed |