SCHEMBL91363

SCHEMBL91363

COCCCn1ncc2ccc(C)cc21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 4/20 0.58
CHRM2 P08172 5/20 0.49
CHRM1 P11229 5/20 0.49
CHRM3 P20309 3/20 0.49
HTR2A P28223 5/20 0.42
HTR2C P28335 5/20 0.42
HTR2B P41595 4/20 0.42
MAPK1 P28482 1/20 0.42
REN P00797 2/20 0.41
MAOB P27338 2/20 0.37
MEN1 O00255 1/20 0.37
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
KMT2A Q03164 1/20 0.37
HTR1A P08908 2/20 0.37
ADRA2A P08913 2/20 0.37
ADRA2B P18089 2/20 0.37
ADRA2C P18825 2/20 0.37
HTR1D P28221 1/20 0.37
HTR7 P34969 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13607536 0.91 KMO (0.61) KMOCHRM2CHRM1CHRM3HTR2A
SCHEMBL3779615 0.84 KMO (0.42) KMOCHRM2CHRM1CHRM3HTR2A
SCHEMBL3777719 0.84 HTR2A (0.44) KMOCHRM2CHRM1CHRM3HTR2A
SCHEMBL3086407 0.83 KMO (0.44) KMOCHRM2CHRM1CHRM3HTR2A
SCHEMBL17504300 0.82 KMO (0.55) KMOCHRM2CHRM1CHRM3HTR2A
SCHEMBL3074398 0.82 KMO (0.43) KMOCHRM2CHRM1CHRM3HTR2A
SCHEMBL78430 0.82 REN (0.50) KMOCHRM2CHRM1CHRM3HTR2A
SCHEMBL3780833 0.82 KMO (0.40) KMOCHRM2CHRM1CHRM3HTR2A
SCHEMBL29354552 0.80 CYP1A2 (0.54) KMOCHRM2CHRM1MAPK1LMNA
SCHEMBL17678149 0.79 KMO (0.58) KMOCHRM2CHRM1CHRM3HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129538-B1 Renin inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-03-06 US disclosed