Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9454876 | 0.76 | PTGS2 (0.44) | KDM4EALDH1A1HSD17B10HPGDGAA | |
| SCHEMBL4229319 | 0.75 | AR (1.00) | ARLOXL2TDP1CYP4A11CA12 | |
| SCHEMBL16880250 | 0.75 | NR4A2 (0.56) | ARKDM4EALDH1A1PTPN5ALOX15 | |
| SCHEMBL69454 | 0.74 | LOXL2 (0.70) | ARKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL16880021 | 0.74 | PTPN5 (0.60) | ARKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL18966722 | 0.73 | ALDH1A1 (0.56) | ARKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL9235475 | 0.72 | AR (0.59) | ARALDH1A1HSD17B10HPGDLOXL2 | |
| SCHEMBL5131182 | 0.71 | PTPN5 (0.63) | ARKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5132934 | 0.71 | PTPN5 (0.63) | ARKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL16155876 | 0.71 | TDP1 (0.77) | ARALDH1A1LOXL2TDP1CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380730-A | Angiotensin antagonist | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-01-10 | — | — | US | disclosed |
| US-5236936-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| EP-0499416-A2 | Pyridine compounds as angiotensin II antagonists, processes for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |