Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.51 |
| ▸ | GPR4 | P46093 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9135835 | 0.91 | AGTR1 (0.49) | AGTR1AGTR2GPR4PPARG | |
| SCHEMBL9135966 | 0.84 | AGTR1 (0.43) | AGTR1AGTR2GPR4 | |
| SCHEMBL8913647 | 0.83 | AGTR1 (0.52) | AGTR1AGTR2GPR4 | |
| L-158809 SCHEMBL683357 | 0.81 | AGTR2 (0.71) | AGTR1AGTR2GPR4 | |
| L-158809 SCHEMBL7944169 | 0.80 | AGTR2 (0.70) | AGTR1AGTR2GPR4 | |
| SCHEMBL9136007 | 0.80 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL8914997 | 0.80 | AGTR1 (0.53) | AGTR1AGTR2GPR4PPARG | |
| SCHEMBL8741166 | 0.78 | AGTR2 (0.61) | AGTR1AGTR2GPR4PPARG | |
| SCHEMBL9426957 | 0.77 | AGTR1 (0.51) | AGTR1AGTR2GPR4PPARG | |
| SCHEMBL9318225 | 0.76 | AGTR1 (0.51) | AGTR1AGTR2GPR4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5387684-A | For treatment and prophylaxis of angiotensin II-mediated diseases such as circulatory diseases of hypertension and heart failure | THE GREEN CROSS CORPORATION (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0602246-A1 | ISOINDAZOLE COMPOUND | THE GREEN CROSS CORPORATION (JP) | 1994-06-22 | — | — | EP | disclosed |