Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.42 |
| ▸ | THRA | P10827 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9255653 | 0.90 | HDAC11 (0.48) | HDAC11HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL9549313 | 0.75 | HDAC1 (0.70) | HDAC11HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL16045114 | 0.74 | HDAC1 (0.72) | HDAC11HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL24193420 | 0.73 | TAS1R3 (0.58) | TAS1R3TAS1R1ALDH1A1HPGDHTT | |
| Bromide SCHEMBL8954063 | 0.72 | UGCG (0.44) | ALDH1A1TP53LMNAMAPT | |
| SCHEMBL8953170 | 0.71 | NPSR1 (0.70) | HDAC11HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL30868632 | 0.71 | TAS1R3 (0.77) | TAS1R3TAS1R1ALDH1A1HTTLMNA | |
| SCHEMBL5483450 | 0.71 | DRD2 (0.60) | HDAC11HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL165896 | 0.71 | PRSS1 (0.61) | TAS1R3TAS1R1ALDH1A1RAB9AMLYCD | |
| SCHEMBL28010260 | 0.70 | TAS1R3 (0.61) | TAS1R3TAS1R1MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5427773-A | Sunscreen agents | ISP VAN DYK INC. (US) | 1995-06-27 | — | — | US | claimed |