Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | DRD4 | P21917 | 3/20 | 0.60 |
| ▸ | DRD3 | P35462 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14430804 | 0.93 | DRD2 (0.57) | DRD2DRD4DRD3MAPTLMNA | |
| SCHEMBL8953170 | 0.91 | NPSR1 (0.70) | DRD2DRD4DRD3ALDH1A1HTR1A | |
| SCHEMBL12132533 | 0.90 | LMNA (0.64) | DRD2DRD4DRD3MAPTLMNA | |
| SCHEMBL14430710 | 0.87 | MAPT (0.58) | MAPTLMNAALDH1A1RECQLGAA | |
| SCHEMBL17194316 | 0.86 | L3MBTL3 (0.64) | DRD2DRD4DRD3MAPTLMNA | |
| SCHEMBL5479770 | 0.85 | SMYD2 (0.61) | MAPTGAASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL13211930 | 0.85 | NPSR1 (0.79) | MAPTLMNAALDH1A1RECQLGAA | |
| SCHEMBL10194869 | 0.83 | NPSR1 (0.81) | MAPTLMNAALDH1A1RECQLGAA | |
| SCHEMBL18502090 | 0.83 | L3MBTL1 (0.61) | DRD2DRD4DRD3MAPTLMNA | |
| SCHEMBL1833770 | 0.83 | POLB (0.62) | MAPTLMNAALDH1A1RECQLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191358-A1 | Novel piperidine derivative for the treatment of depression | GRIN2C, TPH2, HTR5A | DRD2 5/4885DRD4 12/4885DRD3 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.