Indisulam

Indisulam

SCHEMBL91389

NS(=O)(=O)c1ccc(S(=O)(=O)Nc2cccc3c(Cl)c[nH]c23)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 6/20 1.00
CA2 P00918 6/20 1.00
CA9 Q16790 4/20 1.00
CA12 O43570 3/20 1.00
CA3 P07451 1/20 1.00
CA6 P23280 1/20 1.00
CA5A P35218 1/20 1.00
CA7 P43166 1/20 1.00
CRBN Q96SW2 1/20 1.00
CA14 Q9ULX7 1/20 1.00
CA5B Q9Y2D0 1/20 1.00
IMPDH2 P12268 1/20 0.50
PTGES2 Q9H7Z7 5/20 0.48
HTR6 P50406 1/20 0.44
MEN1 O00255 1/20 0.43
TSHR P16473 1/20 0.43
KMT2A Q03164 1/20 0.43
HKDC1 Q2TB90 1/20 0.43
NR3C1 P04150 1/20 0.43
PGR P06401 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indisulam SCHEMBL29799438 1.00 CA1 (1.00) CA1CA2CA9CA12CA3
SCHEMBL3062409 0.91 CA1 (0.83) CA1CA2CA9CA12CA3
SCHEMBL14536224 0.89 CA1 (0.80) CA1CA2CA9CA12CA3
SCHEMBL12190471 0.88 CA1 (0.79) CA1CA2CA9CA12CA3
SCHEMBL7006391 0.88 CA1 (0.79) CA1CA2CA9CA12CA3
SCHEMBL3073932 0.88 CA1 (0.79) CA1CA2CA9CA12CA3
SCHEMBL27634530 0.88 CA1 (0.79) CA1CA2CA9CA12CA3
SCHEMBL3068188 0.88 CA1 (0.79) CA1CA2CA9CA12CA3
SCHEMBL3071891 0.88 CA1 (0.78) CA1CA2CA9CA12CA3
SCHEMBL26265974 0.87 CA1 (0.77) CA1CA2CA9CA12CA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 886 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720329-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS HAVING A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSTIC METHOD SensID GmbH (DE) 2026-04-08 EP claimed
EP-4694892-A1 COMBINATION THERAPY COMPRISING A MAT2A INHIBITOR AND A TOPOISOMERASE INHIBITOR, A SPLICING INHIBITOR SULFONAMIDE, OR A KIF18 INHIBITOR Ideaya Biosciences, Inc. (US) 2026-02-18 EP claimed
US-12551527-B2 Drug delivery systems for treatment of infections WAYNE STATE UNIVERSITY (US) 2026-02-17 US claimed
US-12428459-B2 Protein tag to induce ligand dependent degradation of protein/protein-fusions DANA-FARBER CANCER INSTITUTE, INC. (US) 2025-09-30 US claimed
US-20250295693-A1 HYBRID TUMOR/CANCER THERAPY BASED ON TARGETING THE RESOLUTION OF OR INDUCING TRANSCRIPTION-REPLICATION CONFLICTS (TRCS) JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG (DE) 2025-09-25 US claimed
WO-2025063888-A1 SURVIVIN-TARGETED COMPOUNDS KANCURE PTE. LTD. (SG) 2025-03-27 WO claimed
WO-2025051337-A1 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING ORAL CANCER Afyx Development A/S (DK) 2025-03-13 WO claimed
WO-2024246014-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS HAVING A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSTIC METHOD SENSID GMBH (DE) 2024-12-05 WO claimed
EP-4467659-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS WITH A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSIS SensID GmbH (DE) 2024-11-27 EP claimed
WO-2024216145-A1 COMBINATION THERAPY COMPRISING A MAT2A INHIBITOR AND A TOPOISOMERASE INHIBITOR, A SPLICING INHIBITOR SULFONAMIDE, OR A KIF18 INHIBITOR IDEAYA BIOSCIENCES, INC. (US) 2024-10-17 WO claimed
EP-1622624-A1 MEDICINAL COMPOSITIONS COMPRISING N-(3-CHLORO-1H-INDOL-7-YL)-4-SULFAMOYLBENZENESULFONAMIDE AND FURTHER CYTOSTATICS Eisai Co., Ltd. (JP) 2006-02-08 EP claimed
WO-2004098613-A1 MEDICINAL COMPOSITIONS COMPRISING N-(3-CHLORO-1H-INDOL-7-YL)-4-SULFAMOYLBENZENESULFONAMIDE AND FURTHER CYTOSTATICS EISAI CO., LTD. (JP) 2004-11-18 WO claimed
US-20040224972-A1 Medicinal compositions for concomitant use as anticancer agent EISAI R&D MANAGEMENT CO., LTD. (JP) 2004-11-11 US claimed
US-20040002505-A1 Medicinal compositions for cocominant use as anticancer agent EISAI R&D MANAGEMENT CO., LTD. (JP) 2004-01-01 US claimed
EP-0673937-B1 BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EISAI CO LTD (JP) 2003-11-26 EP claimed
US-20030215523-A1 Medicinal compositions for concomitant use as anticancer agent EISAI R&D MANAGEMENT CO., LTD. (JP) 2003-11-20 US claimed
EP-1331005-A1 MEDICINAL COMPOSITIONS FOR CONCOMINANT USE AS ANTICANCER ATENT Eisai Co., Ltd. (JP) 2003-07-30 EP claimed
US-6060498-A Composition containing antitumor agent EISAI CO., LTD. (JP) 2000-05-09 US claimed
EP-0923932-A1 COMPOSITION CONTAINING ANTITUMOR AGENT Eisai Co., Ltd. (JP) 1999-06-23 EP claimed
EP-0673937-A1 BICYCLIC HETEROCYCLIC SULFONAMIDE AND SULFONIC ESTER DERIVATIVES Eisai Co., Ltd. (JP) 1995-09-27 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040224972-A1 Medicinal compositions for concomitant use as anticancer agent MTDH, TOP2B, TOP1 CA1 490/4885CA2 834/4885CA9 432/4885
US-12551527-B2 Drug delivery systems for treatment of infections PHOSPHO1, PCTP, SGMS1 CA1 3994/4885CA2 4705/4885CA9 4426/4885
US-20030215523-A1 Medicinal compositions for concomitant use as anticancer agent MTDH, TOP2B, TOP1 CA1 490/4885CA2 834/4885CA9 432/4885
US-20040002505-A1 Medicinal compositions for cocominant use as anticancer agent MTDH, TOP2B, CCNH CA1 1895/4885CA2 1930/4885CA9 2051/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.