Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 0.55 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.55 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.55 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.55 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.55 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.55 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.55 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.55 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.55 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.55 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.55 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.55 |
| ▸ | MTOR known ✓ | P42345 | 1/20 | 0.55 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802868 | 0.94 | PKM (0.58) | HTR1ACYP2D6MAPTTSHRTDP1 | |
| Hydrochloric Acid SCHEMBL8807357 | 0.94 | PKM (0.57) | HTR1ACYP2D6MAPTTSHRTDP1 | |
| SCHEMBL8805781 | 0.88 | MAPT (0.49) | HTR1ACYP2D6MAPTTSHRTDP1 | |
| SCHEMBL8805519 | 0.87 | TDP1 (0.52) | HTR1ACYP2D6MAPTTSHRTDP1 | |
| SCHEMBL9136196 | 0.86 | PKM (0.47) | HTR1ACYP2D6MAPTTSHRTDP1 | |
| SCHEMBL8804592 | 0.86 | PKM (0.47) | HTR1ACYP2D6MAPTTSHRTDP1 | |
| SCHEMBL9142476 | 0.85 | MAPT (0.47) | HTR1ACYP2D6MAPTTSHRTDP1 | |
| SCHEMBL8805082 | 0.85 | PKM (0.48) | HTR1ACYP2D6MAPTTSHRTDP1 | |
| SCHEMBL8804387 | 0.85 | PKM (0.51) | HTR1ACYP2D6MAPTTSHRTDP1 | |
| SCHEMBL8804186 | 0.84 | PKM (0.46) | HTR1ACYP2D6MAPTTSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5475105-A | N-substituted azabicycloheptane derivatives | BASF AKTIENGESELLSCHAFT (DE) | 1995-12-12 | — | — | US | disclosed |