Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 1/20 | 0.76 |
| ▸ | SCD | O00767 | 9/20 | 0.73 |
| ▸ | CBFB | Q13951 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | FADS1 | O60427 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254530 | 0.87 | NPBWR1 (1.00) | NPBWR1SCDCBFBCYP1A2CYP2C9 | |
| SCHEMBL913121 | 0.84 | SCD (1.00) | NPBWR1SCDCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL914199 | 0.79 | NPBWR1 (0.79) | NPBWR1SCDCBFBFADS1HDAC6 | |
| SCHEMBL902815 | 0.76 | CBFB (0.64) | NPBWR1SCDCBFBFADS1 | |
| SCHEMBL12568424 | 0.76 | NPBWR1 (0.79) | NPBWR1SCDCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL913764 | 0.75 | SCD (0.85) | NPBWR1SCDCBFBFADS1 | |
| SCHEMBL913129 | 0.74 | SCD (0.79) | NPBWR1SCDFADS1 | |
| SCHEMBL913851 | 0.74 | SCD (0.79) | NPBWR1SCDFADS1 | |
| SCHEMBL913403 | 0.74 | SCD (0.76) | NPBWR1SCDFADS1 | |
| SCHEMBL1586575 | 0.73 | NPBWR1 (0.74) | NPBWR1SCDCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279177-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | Merck Frosst Canada Ltd. (CA) | 2011-02-02 | — | — | EP | disclosed |
| US-20110021532-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. | 2011-01-27 | — | — | US | disclosed |
| US-20110021532-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. | 2011-01-27 | — | — | US | disclosed |
| WO-2009129625-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009129625-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021532-A1 | NOVEL SUBSTITUTED HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | SCD, SCD5, FASN | NPBWR1 3661/4885SCD 1/4885CBFB 918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.