Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7397839 | 0.83 | TRIM24 (0.48) | SIGMAR1MAPTRXFP1HDAC1CDK1 | |
| SCHEMBL7091261 | 0.81 | SIGMAR1 (0.50) | SIGMAR1MAPTRXFP1MAOACDK1 | |
| SCHEMBL14471931 | 0.81 | SIGMAR1 (0.46) | SIGMAR1MAPTRXFP1MAOACYP2D6 | |
| SCHEMBL9491986 | 0.78 | BID (0.47) | SIGMAR1MAPTRXFP1MAOACDK1 | |
| SCHEMBL9428004 | 0.77 | ALDH1A1 (0.65) | SIGMAR1MAPTCDK1MEN1LMNA | |
| SCHEMBL6000358 | 0.77 | ALDH1A1 (0.65) | SIGMAR1MAPTCDK1MEN1LMNA | |
| SCHEMBL10648882 | 0.75 | ALDH1A1 (0.67) | MAPTCDK1MEN1LMNAKMT2A | |
| SCHEMBL9099042 | 0.75 | TRIM24 (0.52) | MAPTHDAC1MEN1LMNATHRB | |
| SCHEMBL9502638 | 0.75 | KDM4E (0.44) | SIGMAR1MAPTRXFP1MEN1KMT2A | |
| SCHEMBL1433686 | 0.74 | SIGMAR1 (0.71) | SIGMAR1MAPTRXFP1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428065-A | Treating central nervous system disorders | LILLY INDUSTRIES LIMITED (GB) | 1995-06-27 | — | — | US | disclosed |
| EP-0645370-A1 | Substituted m-xylylene diamines for the treatment of diseases of the central nervous system | LILLY INDUSTRIES LIMITED (GB) | 1995-03-29 | — | — | EP | disclosed |