SCHEMBL9142256

SCHEMBL9142256

Cc1c[nH]c(=O)nc1N([Si](C)(C)C)[Si](C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ATAD2 Q6PL18 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15743183 0.80 MAT2A (0.37) ATAD2
SCHEMBL9736365 0.79
SCHEMBL6402841 0.79 ALDH1A1 (0.31)
SCHEMBL22008 0.71
SCHEMBL1231792 0.71 ATAD2 (0.37) ATAD2
SCHEMBL7905663 0.70
SCHEMBL4016272 0.70
Water SCHEMBL28196064 0.69 ATAD2 (0.35) ATAD2
Hydrochloric Acid SCHEMBL2199283 0.69 ATAD2 (0.35) ATAD2
SCHEMBL1896687 0.68 MAT2A (0.37) ATAD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5464826-A Antitumor, anticarcinogenic agents, treatment of herpes ELI LILLY AND COMPANY (US) 1995-11-07 US disclosed
EP-0184365-B1 IMPROVEMENTS IN THE TREATMENT OF TUMORS IN MAMMALS ELI LILLY AND COMPANY (US) 1993-08-04 EP disclosed
US-5061793-A Antitumor agents ELI LILLY AND COMPANY (US) 1991-10-29 US disclosed
EP-0184365-A2 Improvements in the treatment of tumors in mammals ELI LILLY AND COMPANY (US) 1986-06-11 EP disclosed