Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | GPX4 | P36969 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9145368 | 0.81 | HTR1A (0.51) | HDAC1HDAC6TRPV1MEN1KMT2A | |
| SCHEMBL9058469 | 0.81 | HTR1A (0.51) | HDAC1HDAC6TRPV1MEN1KMT2A | |
| SCHEMBL22549325 | 0.75 | HTR1A (0.62) | HDAC1HDAC6PRMT5WDR77MEN1 | |
| SCHEMBL29423958 | 0.74 | PRMT5 (0.69) | HDAC1HDAC6PRMT5WDR77 | |
| SCHEMBL24405173 | 0.72 | HTR1A (0.58) | HDAC1HDAC6MEN1KMT2AHTR1A | |
| SCHEMBL29228525 | 0.72 | HDAC6 (1.00) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL29411068 | 0.71 | PRMT5 (0.63) | HDAC1HDAC6PRMT5WDR77GPX4 | |
| SCHEMBL967638 | 0.71 | HDAC1 (0.60) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL10614344 | 0.71 | SIGMAR1 (0.60) | HTR1A | |
| SCHEMBL13203903 | 0.70 | HDAC6 (0.65) | HDAC1HDAC6PRMT5WDR77HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5439915-A | Anxiolytic agents, antidepressants; for central nervous system disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-08-08 | — | — | US | claimed |