Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.61 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8341113 | 0.97 | ESR1 (0.62) | ESR1CLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL11598721 | 0.96 | ESR1 (0.56) | ESR1CLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL8341396 | 0.89 | ESR1 (0.76) | ESR1CLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL8338493 | 0.89 | ESR1 (0.60) | ESR1MEN1KMT2ARAB9ALMNA | |
| SCHEMBL11599689 | 0.84 | ESR1 (0.71) | ESR1CLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL7506018 | 0.82 | ESR1 (0.59) | ESR1MEN1KMT2ARAB9ALMNA | |
| SCHEMBL11600001 | 0.82 | ESR1 (0.67) | ESR1 | |
| SCHEMBL11599683 | 0.80 | MAOB (0.59) | MEN1KMT2ARAB9AMAPTMAOB | |
| SCHEMBL11599731 | 0.80 | MAOB (0.53) | ESR1CLK1DYRK1ADYRK1BMAOB | |
| SCHEMBL8338171 | 0.78 | ESR1 (0.63) | ESR1CLK1DYRK1ADYRK1BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5445941-A | Using nucleic acids from the promoter regions of transforming growth factor beta genes comprising novel regulatory elements designated \"raloxifene responsive elements\ | ELI LILLY AND COMPANY (US) | 1995-08-29 | — | — | US | disclosed |
| US-4075227-A | NONSTEROIDAL | ELI LILLY AND COMPANY (US) | 1978-02-21 | — | — | US | disclosed |