Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADH1B | P00325 | 1/20 | 0.36 |
| ▸ | ADH1C | P00326 | 1/20 | 0.36 |
| ▸ | ADH1A | P07327 | 1/20 | 0.36 |
| ▸ | ADH4 | P08319 | 1/20 | 0.36 |
| ▸ | ADH7 | P40394 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598223 | 0.86 | TSHR (0.39) | TSHRSMN1; SMN2CTSKADH1BADH1C | |
| SCHEMBL28853381 | 0.82 | ADH1B (0.50) | TSHRSMN1; SMN2ADH1BADH1CADH1A | |
| SCHEMBL27260031 | 0.81 | TSHR (0.42) | TSHRSMN1; SMN2CTSKADH1BADH1C | |
| SCHEMBL5365130 | 0.80 | — | — | |
| SCHEMBL27861734 | 0.79 | TSHR (0.41) | TSHRSMN1; SMN2CTSKCYP3A4ADH1B | |
| SCHEMBL28196129 | 0.79 | ALDH1A1 (0.45) | TSHRSMN1; SMN2CTSKALDH1A1CYP3A4 | |
| SCHEMBL27278114 | 0.79 | TSHR (0.38) | TSHRSMN1; SMN2CTSKALDH1A1CYP3A4 | |
| SCHEMBL18967347 | 0.78 | ADH1B (0.47) | TSHRSMN1; SMN2ADH1BADH1CADH1A | |
| SCHEMBL25295858 | 0.77 | TSHR (0.52) | TSHRSMN1; SMN2CTSKALDH1A1CYP3A4 | |
| SCHEMBL28701042 | 0.77 | CA1 (0.44) | TSHRSMN1; SMN2CYP3A4ADH1BADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5352689-A | Rhizoxin derivatives and their use as anti-tumor agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-04 | — | — | US | claimed |
| EP-3227255-A1 | INTERMEDIATES AND PROCESS FOR THE PREPARATION OF SANDALWOOD OIL BUILDING BLOCKS | Firmenich SA (CH) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016087179-A1 | INTERMEDIATES AND PROCESS FOR THE PREPARATION OF SANDALWOOD OIL BUILDING BLOCKS | FIRMENICH SA (CH) | 2016-06-09 | — | — | WO | disclosed |
| US-5391564-A | E.g., rhizoxin-13-yl 3-methylthiopropionate; anticarcinogenic agents | SANKYO COMPANY, LIMITED (JP) | 1995-02-21 | — | — | US | disclosed |
| US-5389626-A | 3-aryloxmethyl-cephalosporin derivatives, and their medical use | SANKYO COMPANY, LIMITED (JP) | 1995-02-14 | — | — | US | disclosed |
| US-5352689-A | Rhizoxin derivatives and their use as anti-tumor agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0350315-B1 | RHIZOXIN DERIVATES AND THEIR USE AS ANTI-TUMOR AGENTS | SANKYO COMPANY LIMITED (JP) | 1993-06-16 | — | — | EP | disclosed |
| EP-0363223-A2 | 3-Aryloxymethyl-cephalosporin derivatives, their preparation and their medical use | Sankyo Company Limited (JP) | 1990-04-11 | — | — | EP | disclosed |
| EP-0350315-A1 | Rhizoxin derivates and their use as anti-tumor agents | SANKYO COMPANY LIMITED (JP) | 1990-01-10 | — | — | EP | disclosed |