Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | ADH1B | P00325 | 1/20 | 0.30 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
| ▸ | ADH1A | P07327 | 1/20 | 0.30 |
| ▸ | ADH4 | P08319 | 1/20 | 0.30 |
| ▸ | ADH7 | P40394 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9147679 | 0.86 | TSHR (0.52) | TSHRSMN1; SMN2CTSKADH1BADH1C | |
| SCHEMBL5365130 | 0.84 | — | — | |
| SCHEMBL6543947 | 0.75 | ALDH1A1 (0.32) | TSHRSMN1; SMN2 | |
| SCHEMBL11939964 | 0.74 | — | — | |
| SCHEMBL1410409 | 0.74 | — | — | |
| SCHEMBL4756088 | 0.74 | — | — | |
| SCHEMBL18967347 | 0.73 | ADH1B (0.47) | TSHRSMN1; SMN2ADH1BADH1CADH1A | |
| SCHEMBL21807482 | 0.72 | TSHR (0.41) | TSHRSMN1; SMN2LMNAMETAP1 | |
| SCHEMBL28853381 | 0.71 | ADH1B (0.50) | TSHRSMN1; SMN2LMNAADH1BADH1C | |
| SCHEMBL1404786 | 0.71 | LMNA (0.48) | TSHRLMNAMETAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5352689-A | Rhizoxin derivatives and their use as anti-tumor agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-04 | — | — | US | claimed |
| EP-2277504-A1 | Substituted tetracycline compounds for the treatment of malaria | Paratek Pharmaceuticals, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| EP-0492847-B2 | Air curing polymer composition | ROHM & HAAS (US) | 2002-11-20 | — | — | EP | disclosed |
| CN-1031138-C | Air-curing polymer composition | ROHM & HAAS (US) | 1996-02-28 | — | — | CN | disclosed |
| US-5391564-A | E.g., rhizoxin-13-yl 3-methylthiopropionate; anticarcinogenic agents | SANKYO COMPANY, LIMITED (JP) | 1995-02-21 | — | — | US | disclosed |
| US-5389626-A | 3-aryloxmethyl-cephalosporin derivatives, and their medical use | SANKYO COMPANY, LIMITED (JP) | 1995-02-14 | — | — | US | disclosed |
| US-5352689-A | Rhizoxin derivatives and their use as anti-tumor agents | SANKYO COMPANY, LIMITED (JP) | 1994-10-04 | — | — | US | disclosed |
| EP-0350315-B1 | RHIZOXIN DERIVATES AND THEIR USE AS ANTI-TUMOR AGENTS | SANKYO COMPANY LIMITED (JP) | 1993-06-16 | — | — | EP | disclosed |
| CN-1062543-A | The polymer composition of air curing | ROHM & HAAS (US) | 1992-07-08 | — | — | CN | disclosed |
| EP-0363223-A2 | 3-Aryloxymethyl-cephalosporin derivatives, their preparation and their medical use | Sankyo Company Limited (JP) | 1990-04-11 | — | — | EP | disclosed |
| EP-0350315-A1 | Rhizoxin derivates and their use as anti-tumor agents | SANKYO COMPANY LIMITED (JP) | 1990-01-10 | — | — | EP | disclosed |