SCHEMBL9148183

SCHEMBL9148183

CCCC[C@H](NC(=O)OC(C)(C)C)C(O)c1c(-c2ccccc2C)c1=O

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTSK P43235 15/20 0.43
CTSS P25774 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9148295 0.86 CTSK (0.50) CTSKCTSS
SCHEMBL9148271 0.81 CTSK (0.46) CTSKCTSS
SCHEMBL9150305 0.77 CTSK (0.38) CTSKCTSS
SCHEMBL8393511 0.75 CTSK (0.38) CTSKCTSS
SCHEMBL9411735 0.74 CTSK (0.45) CTSKCTSS
SCHEMBL8393547 0.74 CTSK (0.46) CTSKCTSS
SCHEMBL9146250 0.73 CTSK (0.44) CTSKCTSS
SCHEMBL7344729 0.72 REN (0.49) CTSKCTSS
SCHEMBL26192966 0.71 CTSK (0.53) CTSKCTSS
SCHEMBL9052905 0.71 CTSK (0.44) CTSKCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5395958-A Intermediates for enzyme inhibitors MITSUBISHI KASEI CORPORATION (JP) 1995-03-07 US disclosed
EP-0590650-A1 Cyclopropene derivatives with thiol protease inhibiting activity Mitsubishi Chemical Corporation (JP) 1994-04-06 EP disclosed