SCHEMBL9148591

SCHEMBL9148591

CC[C@H](C)COc1ccc(-c2ccc(O)cc2)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 2/20 0.41
ERN1 O75460 1/20 0.41
XDH P47989 1/20 0.40
CYP3A4 P08684 1/20 0.40
AAK1 Q2M2I8 1/20 0.40
ADRB3 P13945 6/20 0.38
TLR8 Q9NR97 1/20 0.37
NPSR1 Q6W5P4 1/20 0.36
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
ESR1 P03372 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9148922 0.85 HPGD (0.39) ESR2ERN1XDHADRB3NPSR1
SCHEMBL9144904 0.84 CYP3A4 (0.44) ERN1XDHCYP3A4AAK1NPSR1
SCHEMBL10349477 0.83 XDH (0.41) XDHTLR8LMNAESR1
SCHEMBL9149072 0.83 CYP17A1 (0.41) ESR2ERN1CYP3A4AAK1TLR8
SCHEMBL10349480 0.80 XDH (0.54) XDHCYP3A4AAK1
SCHEMBL6938802 0.77 FFAR1 (0.50) ESR2CYP3A4AAK1ADRB3
SCHEMBL7686129 0.77 FFAR1 (0.50) ESR2CYP3A4AAK1ADRB3
SCHEMBL9148575 0.77 SMN1; SMN2 (0.42) TP53
SCHEMBL9148886 0.76 ALOX15 (0.44) XDH
SCHEMBL9150204 0.76 ALOX15 (0.44) XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5397504-A Liquid crystal KANTO KAGAKU KABUSHIKI KAISHA (JP) 1995-03-14 US disclosed
EP-0315701-B1 BIPHENYL COMPOUND KANTO KAGAKU (JP) 1993-12-29 EP disclosed
EP-0315701-A1 BIPHENYL COMPOUND KANTO KAGAKU KABUSHIKI KAISHA (JP) 1989-05-17 EP disclosed