Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.50 |
| ▸ | MAOA | P21397 | 6/20 | 0.50 |
| ▸ | MAOB | P27338 | 6/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9145611 | 0.92 | KDM1A (0.60) | KDM1AMAOAMAOBDRD2DRD3 | |
| SCHEMBL9144599 | 0.85 | GID4 (0.54) | KDM1AMAOAMAOBSIGMAR1HTR2C | |
| SCHEMBL9147856 | 0.80 | KDM1A (0.51) | KDM1AMAOAMAOBDRD2DRD3 | |
| SCHEMBL783586 | 0.79 | DRD2 (0.53) | KDM1AMAOAMAOBDRD2DRD3 | |
| SCHEMBL30563659 | 0.78 | ACHE (0.60) | DRD2DRD3CYP19A1CYP11B1SIGMAR1 | |
| SCHEMBL4418237 | 0.78 | ACHE (0.60) | DRD2DRD3CYP19A1CYP11B1SIGMAR1 | |
| SCHEMBL269087 | 0.78 | ACHE (0.60) | DRD2DRD3CYP19A1CYP11B1SIGMAR1 | |
| SCHEMBL2463469 | 0.78 | ACHE (0.60) | DRD2DRD3CYP19A1CYP11B1SIGMAR1 | |
| SCHEMBL30563644 | 0.78 | ACHE (0.60) | DRD2DRD3CYP19A1CYP11B1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5969966 | 0.76 | ACHE (0.62) | DRD2DRD3CYP19A1CYP11B1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5416118-A | Enzyme inhibitors | SCHERING CORPORATION (US) | 1995-05-16 | — | — | US | disclosed |
| EP-0583346-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1994-02-23 | — | — | EP | disclosed |
| WO-1992018462-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1992-10-29 | — | — | WO | disclosed |
| EP-0508425-A1 | Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase | SCHERING CORPORATION (US) | 1992-10-14 | — | — | EP | disclosed |