Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9155142 | 0.85 | ALDH1A1 (0.57) | ALDH1A1ALOX15PKMKDM4EMAPT | |
| SCHEMBL9153206 | 0.81 | KMT2A (0.39) | ALDH1A1ALOX15PKMKDM4EMAPT | |
| SCHEMBL13236204 | 0.78 | ALDH1A1 (0.64) | ALDH1A1ALOX15PKMKDM4EMAPT | |
| SCHEMBL9153024 | 0.77 | ALDH1A1 (0.57) | ALDH1A1ALOX15PKMKDM4EMAPT | |
| SCHEMBL9505295 | 0.76 | PKM (0.64) | ALDH1A1ALOX15PKMKDM4EMAPT | |
| SCHEMBL7543877 | 0.76 | MAPT (0.49) | ALDH1A1KDM4EMAPTPOLBHPGD | |
| SCHEMBL9152872 | 0.76 | ALDH1A1 (0.66) | ALDH1A1KDM4EMAPTHSD17B10POLB | |
| SCHEMBL9148866 | 0.75 | TTR (0.53) | ALDH1A1ALOX15PKMKDM4EMAPT | |
| SCHEMBL8846863 | 0.74 | HSD17B10 (0.70) | ALDH1A1PKMMAPTHSD17B10L3MBTL1 | |
| SCHEMBL9149091 | 0.73 | HRH3 (0.61) | ALDH1A1ALOX15PKMKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5385922-A | Cardiovascular and gastrointestinal disorders; antiischemic and cardiotonic agents | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-31 | — | — | US | disclosed |