Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MDH1 | P40925 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9150905 | 0.84 | LTB4R (0.45) | MAPTLTB4RTTRALDH1A1KDM4E | |
| SCHEMBL9149226 | 0.79 | LTB4R (0.58) | MAPTLTB4RALDH1A1KDM4EHPGD | |
| SCHEMBL9150794 | 0.79 | TTR (0.44) | MAPTTTRALDH1A1KDM4EGAA | |
| SCHEMBL9149095 | 0.74 | TTR (0.46) | MAPTTTRALDH1A1KDM4EGAA | |
| SCHEMBL9150025 | 0.73 | LTB4R (0.44) | MAPTLTB4RALDH1A1KDM4EGAA | |
| SCHEMBL9150792 | 0.71 | LTB4R (0.45) | LTB4RTTRALDH1A1KDM4EGAA | |
| SCHEMBL9147978 | 0.70 | LTB4R (0.45) | MAPTLTB4RTTRALDH1A1KDM4E | |
| SCHEMBL9150347 | 0.68 | LTB4R (0.76) | MAPTLTB4RALDH1A1KDM4EHPGD | |
| SCHEMBL9150723 | 0.66 | LTB4R (0.76) | LTB4RALDH1A1KDM4EHPGDCYP2C9 | |
| SCHEMBL9150788 | 0.66 | LTB4R (0.47) | MAPTLTB4RTTRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442748-B1 | Improvements in and relating to leukotriene antagonists | LILLY CO ELI (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0442748-A1 | Improvements in and relating to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1991-08-21 | — | — | EP | disclosed |
| US-4996230-A | Antiallergens, antiinflammatory agent | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |