Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9147978 | 0.86 | LTB4R (0.45) | LTB4RRAB9AALDH1A1KDM4ENPC1 | |
| SCHEMBL9150025 | 0.85 | LTB4R (0.44) | LTB4RRAB9AALDH1A1KDM4EGAA | |
| SCHEMBL9150905 | 0.84 | LTB4R (0.45) | LTB4RRAB9AALDH1A1KDM4EGLA | |
| SCHEMBL9150787 | 0.75 | LTB4R (0.72) | LTB4RRAB9AALDH1A1KDM4EGLA | |
| SCHEMBL9149236 | 0.71 | MAPT (0.39) | LTB4RALDH1A1KDM4EGAANPC1 | |
| SCHEMBL9150020 | 0.70 | LTB4R (0.71) | LTB4RALDH1A1KDM4EGLAGAA | |
| SCHEMBL9149095 | 0.70 | TTR (0.46) | RAB9AALDH1A1KDM4EGLAGAA | |
| SCHEMBL9151115 | 0.70 | CLEC4M (0.43) | RAB9AALDH1A1KDM4EGLAGAA | |
| SCHEMBL9150038 | 0.68 | RAB9A (0.44) | RAB9AALDH1A1KDM4EGLAGAA | |
| SCHEMBL9150895 | 0.67 | LTB4R (0.73) | LTB4RALDH1A1KDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442748-B1 | Improvements in and relating to leukotriene antagonists | LILLY CO ELI (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0442748-A1 | Improvements in and relating to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1991-08-21 | — | — | EP | disclosed |
| US-4996230-A | Antiallergens, antiinflammatory agent | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |