Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.46 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.46 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.46 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.46 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.46 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.46 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.46 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.46 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.46 |
| ▸ | CACNA1E | Q15878 | 2/20 | 0.46 |
| ▸ | CACNA2D4 | Q7Z3S7 | 2/20 | 0.46 |
| ▸ | CACNA2D3 | Q8IZS8 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182200 | 0.88 | MAPK1 (0.52) | LMNATSHRSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9148901 | 0.83 | LMNA (0.46) | ACHECACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL21836697 | 0.80 | MAPT (0.46) | ACHELMNAALDH1A1NPSR1MAPT | |
| SCHEMBL26690229 | 0.77 | MAPT (0.43) | ACHELMNATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL23850047 | 0.75 | LMNA (0.46) | LMNASMN1; SMN2ALDH1A1NPSR1MAPT | |
| SCHEMBL15937184 | 0.74 | TP53 (0.48) | LMNAHTTTSHRALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL17317527 | 0.74 | ALDH1A1 (0.41) | LMNAALDH1A1NPSR1KDM4ETP53 | |
| SCHEMBL23850212 | 0.73 | CYP19A1 (0.42) | LMNAHTTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL1432075 | 0.73 | TSHR (0.41) | LMNAHTTTSHRALDH1A1NPSR1 | |
| SCHEMBL9937024 | 0.73 | UCHL1 (0.48) | HTTSMN1; SMN2ALDH1A1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5387693-A | Intermediates for inhibitors of cholesterol biosynthesis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-02-07 | — | — | US | disclosed |
| US-5315012-A | Prevention of hypercholesterolemia, hyperlipoproteinemia and atherosclerosis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-24 | — | — | US | disclosed |
| US-5250561-A | Anticholesterool agents; prevention of hyperlipoproteinemia and atherosclerosis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0529854-A2 | Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-COA reductase inhibitors | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-03-03 | — | — | EP | disclosed |
| US-5134155-A | Anticholesterol | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |