Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.58 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 8/20 | 0.56 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1349005 | 0.89 | TOP2A (0.58) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL9152025 | 0.88 | TOP2A (0.55) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL9266645 | 0.88 | TOP2A (0.47) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL9728366 | 0.88 | GSK3B (0.58) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL9145544 | 0.88 | TOP2A (0.61) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL9151682 | 0.88 | TOP2A (0.55) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL8785054 | 0.86 | TOP2A (0.53) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL8784501 | 0.85 | TOP2A (0.49) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL1344780 | 0.85 | MEN1 (0.68) | TOP2ATOP2BMEN1KMT2AGSK3B | |
| SCHEMBL9148194 | 0.82 | ADRB2 (0.55) | TOP2ATOP2BMEN1KMT2AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607825-A1 | 6-H-4-OXO-3-quinoline-carboxylic acids and their analogues as antibacterial agents | BAYER AG (DE) | 1994-07-27 | — | — | EP | claimed |
| EP-0200307-A1 | Improved process for production of quinoline-3-carboxylic acid antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-11-05 | — | — | EP | claimed |
| US-5457104-A | Antibacterials | BAYER AKTIENGESELLSCHAFT (DE) | 1995-10-10 | — | — | US | disclosed |
| EP-0607825-A1 | 6-H-4-OXO-3-quinoline-carboxylic acids and their analogues as antibacterial agents | BAYER AG (DE) | 1994-07-27 | — | — | EP | disclosed |
| EP-0200307-A1 | Improved process for production of quinoline-3-carboxylic acid antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-11-05 | — | — | EP | disclosed |