Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.58 |
| ▸ | TOP2A | P11388 | 5/20 | 0.58 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.56 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9149448 | 0.88 | TOP2A (0.58) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL9151682 | 0.85 | TOP2A (0.55) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL9152025 | 0.85 | TOP2A (0.55) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL9145544 | 0.85 | TOP2A (0.61) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL1349005 | 0.83 | TOP2A (0.58) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL9146810 | 0.83 | ADRB2 (0.52) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL8785054 | 0.83 | TOP2A (0.53) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL1345769 | 0.82 | GSK3B (0.70) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL1344780 | 0.81 | MEN1 (0.68) | GSK3BTOP2ATOP2BCACNA1FPOLB | |
| SCHEMBL4716155 | 0.81 | GSK3B (0.59) | GSK3BTOP2ATOP2BCACNA1FPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153203-A | QUINOLONE DERIVATIVES AND SALTS THEREOF, PREPARATION PROCESSES THEREOF, AND ANTIBACTERIAL AGENTS CONTAINING THE SAME | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1992-10-06 | — | — | US | disclosed |
| EP-0390215-A2 | Quinolone derivatives and salts thereof, preparation process es thereof, and antibacterial agents containing the same | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1990-10-03 | — | — | EP | disclosed |