Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.54 |
| ▸ | THRB | P10828 | 8/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725192 | 0.82 | THRA (0.61) | THRATHRBNPC1RAB9AKMT2A | |
| SCHEMBL9151866 | 0.80 | THRA (0.66) | THRATHRBNPC1RAB9ACASP3 | |
| SCHEMBL28128459 | 0.78 | KMT2A (0.55) | NPC1RAB9AKMT2ACASP3SENP8 | |
| SCHEMBL9154172 | 0.78 | THRA (0.53) | THRATHRBNPC1RAB9AKMT2A | |
| SCHEMBL9148552 | 0.78 | THRA (0.59) | THRATHRBNPC1RAB9A | |
| SCHEMBL9150875 | 0.78 | THRA (0.59) | THRATHRBNPC1RAB9ALMNA | |
| SCHEMBL9151000 | 0.77 | NPC1 (0.64) | THRATHRBNPC1RAB9AEGFR | |
| Hydrochloric Acid SCHEMBL9725207 | 0.77 | THRA (0.58) | THRATHRBNPC1RAB9ALMNA | |
| SCHEMBL7069304 | 0.76 | SIGMAR1 (0.56) | THRATHRBNPC1RAB9ACASP3 | |
| SCHEMBL9151826 | 0.76 | THRA (0.57) | THRATHRBNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401798-B1 | Substituted aminoalkylbenzene derivatives | HOFFMANN LA ROCHE (CH) | 1995-01-11 | — | — | EP | claimed |
| EP-0401798-B1 | Substituted aminoalkylbenzene derivatives | HOFFMANN LA ROCHE (CH) | 1995-01-11 | — | — | EP | disclosed |
| US-5137920-A | METHOD OF TREATING FUNGAL INFECTIONS | HOFFMANN-LA ROCHE INC. (US) | 1992-08-11 | — | — | US | disclosed |