Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9372780 | 0.87 | KCNH2 (0.61) | DRD2SLC6A4ADRA1DHTR2AKCNH2 | |
| SCHEMBL9150449 | 0.82 | DRD2 (0.49) | DRD2SLC6A4ADRA1DHTR2AKCNH2 | |
| SCHEMBL23010845 | 0.78 | APP (0.64) | DRD2SLC6A4ADRA1D | |
| SCHEMBL9149801 | 0.75 | KCNH2 (0.61) | DRD2SLC6A4ADRA1DHTR2AKCNH2 | |
| SCHEMBL6958224 | 0.75 | HTR1A (0.66) | DRD2 | |
| SCHEMBL9153282 | 0.75 | KCNH2 (0.77) | DRD2SLC6A4ADRA1DHTR2AKCNH2 | |
| SCHEMBL8642590 | 0.73 | HTR1A (0.80) | DRD2SLC6A4ADRA1DHTR2AKCNH2 | |
| SCHEMBL18324794 | 0.72 | IDO1 (0.47) | DRD2SLC6A4ADRA1DHTR2AKCNH2 | |
| SCHEMBL4676883 | 0.72 | HTR2C (0.62) | DRD2SLC6A4HTR2A | |
| SCHEMBL9153185 | 0.72 | ADRA1D (0.52) | SLC6A4ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5457115-A | Treating anxiety, depression, sleep disorders, migranes, schizophrenia or Parkinson's disease in humans | H. LUNDBECK A/S (DK) | 1995-10-10 | — | — | US | disclosed |
| EP-0465398-B1 | Novel indole derivatives | LUNDBECK & CO AS H (DK) | 1994-12-14 | — | — | EP | disclosed |
| US-5322851-A | Indole derivatives | H. LUNDBECK A/S (DK) | 1994-06-21 | — | — | US | disclosed |
| US-5216001-A | Central nervous system disorders | H. LUNBECK A/S (DK) | 1993-06-01 | — | — | US | disclosed |
| EP-0465398-A2 | Novel indole derivatives | H. LUNDBECK A/S (DK) | 1992-01-08 | — | — | EP | disclosed |