Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.59 |
| ▸ | HTR2A | P28223 | 5/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.59 |
| ▸ | HTR2B | P41595 | 4/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL278451 | 0.85 | HRH3 (0.71) | CYP2D6GRIN2BADRA2AHTR2AADRA1A | |
| SCHEMBL4748684 | 0.82 | GRIN2B (0.57) | CYP2D6GRIN2BADRA2AHTR2AADRA1A | |
| SCHEMBL6773183 | 0.82 | CYP2D6 (0.61) | CYP2D6LMNAOPRK1 | |
| SCHEMBL9735226 | 0.82 | CCR3 (0.60) | CYP2D6GRIN2BADRA2AHTR2AADRA1A | |
| SCHEMBL10735593 | 0.82 | GRIN2B (0.85) | CYP2D6GRIN2BADRA2AHTR2AADRA1A | |
| Hydrochloric Acid SCHEMBL30390347 | 0.81 | GRIN2B (0.56) | CYP2D6GRIN2BADRA2AHTR2AADRA1A | |
| SCHEMBL14463383 | 0.81 | OPRM1 (0.60) | CYP2D6GRIN2BADRA2AHTR2AADRA1A | |
| SCHEMBL24486057 | 0.79 | GRIN2B (0.54) | CYP2D6GRIN2BADRA2AHTR2AADRA1A | |
| SCHEMBL11134420 | 0.79 | GRIN2B (0.69) | CYP2D6GRIN2BADRA2AHTR2AADRA1A | |
| SCHEMBL7405479 | 0.79 | OPRK1 (0.52) | CYP2D6GRIN2BADRA2AHTR2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5457115-A | Treating anxiety, depression, sleep disorders, migranes, schizophrenia or Parkinson's disease in humans | H. LUNDBECK A/S (DK) | 1995-10-10 | — | — | US | disclosed |
| US-5322851-A | Indole derivatives | H. LUNDBECK A/S (DK) | 1994-06-21 | — | — | US | disclosed |
| US-5216001-A | Central nervous system disorders | H. LUNBECK A/S (DK) | 1993-06-01 | — | — | US | disclosed |
| EP-0465398-A2 | Novel indole derivatives | H. LUNDBECK A/S (DK) | 1992-01-08 | — | — | EP | disclosed |