SCHEMBL9150683

SCHEMBL9150683

CCOC(=O)Nc1ccc(Cl)c(OC2CCCC2)c1F

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
KCNQ3 O43525 2/20 0.40
KCNQ2 O43526 2/20 0.40
TLR4 O00206 4/20 0.40
CHRM3 P20309 4/20 0.39
RECQL P46063 1/20 0.39
LMNA P02545 1/20 0.38
SUCNR1 Q9BXA5 2/20 0.38
NPC1 O15118 1/20 0.38
POLB P06746 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9146354 0.77 CXCR2 (0.36) CHRM3SUCNR1
SCHEMBL7922423 0.77 SCN9A (0.48) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL10941925 0.72 ALDH1A1 (0.48) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL12760866 0.70 MAOA (0.46) ALDH1A1SMN1; SMN2LMNAPOLBRAB9A
SCHEMBL8886746 0.70 ALOX15 (0.51) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL9376422 0.70 CYP1A2 (0.58) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL2069938 0.68 CYP19A1 (0.60) ALDH1A1CYP1A2CYP2C19SMN1; SMN2LMNA
SCHEMBL30076159 0.68 ALDH1A1 (0.51) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL27248809 0.68 ALDH1A1 (0.51) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL6237270 0.68 SMN1; SMN2 (0.48) ALDH1A1CYP1A2CYP2C9CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5464811-A Benzene derivatives substituted with heterocyclic ring and herbicides containing same as active ingredients SAGAMI CHEMICAL RESEARCH CENTER (JP) 1995-11-07 US disclosed