Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | HTR1A | P08908 | 6/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.38 |
| ▸ | KHK | P50053 | 3/20 | 0.37 |
| ▸ | USP14 | P54578 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9150837 | 0.79 | HTR6 (0.40) | RENKCNH2HTR1ASLC6A2SLC6A4 | |
| SCHEMBL28216093 | 0.70 | HTR2C (0.44) | KCNH2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11245466 | 0.68 | SIGMAR1 (0.42) | RENUSP14SIGMAR1 | |
| SCHEMBL5254443 | 0.68 | CYP11B2 (0.46) | KCNH2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2565277 | 0.68 | CCR3 (0.61) | HTR1ASLC6A2SLC6A4SLC6A3KHK | |
| SCHEMBL29385 | 0.66 | KDM4E (0.67) | RENUSP14 | |
| SCHEMBL11670374 | 0.65 | HTR6 (0.40) | RENUSP14SIGMAR1HTR2AHTR2C | |
| SCHEMBL14540707 | 0.64 | PLAT (0.41) | KCNH2HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9150726 | 0.64 | KCNH2 (0.61) | KCNH2 | |
| Hydrochloric Acid SCHEMBL31078540 | 0.63 | HTR6 (0.48) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5457115-A | Treating anxiety, depression, sleep disorders, migranes, schizophrenia or Parkinson's disease in humans | H. LUNDBECK A/S (DK) | 1995-10-10 | — | — | US | disclosed |
| EP-0465398-B1 | Novel indole derivatives | LUNDBECK & CO AS H (DK) | 1994-12-14 | — | — | EP | disclosed |
| US-5322851-A | Indole derivatives | H. LUNDBECK A/S (DK) | 1994-06-21 | — | — | US | disclosed |
| US-5216001-A | Central nervous system disorders | H. LUNBECK A/S (DK) | 1993-06-01 | — | — | US | disclosed |