Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.60 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.60 |
| ▸ | PHF8 | Q9UPP1 | 7/20 | 0.55 |
| ▸ | KDM2A | Q9Y2K7 | 7/20 | 0.55 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.53 |
| ▸ | KDM5C | P41229 | 5/20 | 0.52 |
| ▸ | KDM6B | O15054 | 3/20 | 0.52 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.52 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.45 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL28100221 | 0.88 | LMNA (0.65) | LMNAOR51E2SLC22A6TSHRTHRB | |
| Succinic Acid SCHEMBL5875148 | 0.86 | EGLN1 (0.69) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Succinic Acid SCHEMBL5875155 | 0.86 | EGLN1 (0.69) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Succinic Acid SCHEMBL5874481 | 0.82 | LMNA (0.75) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Succinic Acid SCHEMBL5874486 | 0.82 | LMNA (0.75) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| SCHEMBL29955022 | 0.81 | — | — | |
| Succinic Acid SCHEMBL3628497 | 0.78 | EGLN1 (0.82) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Succinic Acid SCHEMBL30575212 | 0.78 | EGLN1 (0.82) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Succinic Acid SCHEMBL27584447 | 0.78 | EGLN1 (0.82) | EGLN1LMNAALKBH5SUCNR1PHF8 | |
| Succinic Acid SCHEMBL28729193 | 0.78 | LMNA (0.82) | EGLN1LMNAALKBH5SUCNR1PHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5472946-A | Topical administration of lincomycin, clindamycin, erthromycin and iododeoxyuridine on skin or mucuous membranes | DISCOVERY THERAPEUTICS, INC. | 1995-12-05 | — | — | US | disclosed |
| EP-0582065-A1 | 1-Oxohydrocarbyl-substituted azacyclohexanes compositions used as acid catalyst | WHITBY RESEARCH, Inc. (US) | 1994-02-09 | — | — | EP | disclosed |
| CN-1080472-A | Antifungal and herbicidal triazoles | ROHM & HAAS (US) | 1994-01-12 | — | — | CN | disclosed |
| EP-0416034-A4 | PENETRATION ENHANCERS FOR TRANSDERMAL DELIVERY OF SYSTEMIC AGENT | — | 1992-04-01 | — | — | EP | disclosed |
| EP-0416034-A1 | PENETRATION ENHANCERS FOR TRANSDERMAL DELIVERY OF SYSTEMIC AGENT | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0267277-A4 | COMPOSITIONS COMPRISING 1-SUBSTITUTED LACTAMS. | NELSON RES & DEV COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| EP-0280703-A4 | COMPOSITIONS COMPRISING 1-ACYL-SUBSTITUTED MORPHOLINES, THIOMORPHOLINES AND PIPERAZINES AND THEIR USES. | NELSON RES & DEV COMPANY (US) | 1990-01-08 | — | — | EP | disclosed |
| EP-0329669-A4 | COMPOSITIONS COMPRISING N,N-DIALKYLALKANAMIDES AND THEIR USES. | NELSON RES & DEV COMPANY (US) | 1989-12-12 | — | — | EP | disclosed |
| US-4886545-A | IMPROVE DELIVERY OF PLANT NUTRIENTS | NELSON RESEARCH & DEVELOPMENT COMPANY (US) | 1989-12-12 | — | — | US | disclosed |
| WO-1989011222-A1 | PENETRATION ENHANCERS FOR TRANSDERMAL DELIVERY OF SYSTEMIC AGENT | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-11-30 | — | — | WO | disclosed |
| WO-1987004593-A1 | COMPOSITIONS COMPRISING 1-SUBSTITUTED AZACYCLOALKANES AND THEIR USES | NELSON RESEARCH AND DEVELOPMENT COMPANY (US) | 1987-08-13 | — | — | WO | disclosed |
| US-4581056-A | Synergistic senescence delaying foliar fertilizer composition and method of using same to delay senescence in field crops | THE BOARD OF REGENTS OF UNIVERSITY OF MICHIGAN, CORP. OF MICHIGAN (US) | 1986-04-08 | — | — | US | disclosed |
| US-4431437-A | ADDING A PHYTOTOXICITY-PROMOTING MIXTURE OF N-METHYLPYRROLIDONE OR POLYVINYLPYRROLIDONE AND A 2-HALOETHYL PHOSPHONIC ACID | GAF CORPORATION (US) | 1984-02-14 | — | — | US | disclosed |
| EP-0026392-B1 | THE USE OF 1-(ALKANOYL) GUANIDINES AS FUNGICIDES | GAF CORPORATION (US) | 1982-09-08 | — | — | EP | disclosed |
| EP-0056261-A1 | Bioactant translocation agent | GAF CORPORATION (US) | 1982-07-21 | — | — | EP | disclosed |
| US-4328026-A | PLANT GROWTH REGULATORS, ETHYLENE GENERATORS | GAF CORPORATION (US) | 1982-05-04 | — | — | US | disclosed |
| EP-0026392-A1 | The use of 1-(alkanoyl) guanidines as fungicides | GAF CORPORATION (US) | 1981-04-08 | — | — | EP | disclosed |
| US-4251545-A | Fungicidal process using 1-(alkoxyaroyl)guanidines | GAF CORPORATION (US) | 1981-02-17 | — | — | US | disclosed |
| US-4251544-A | Fungicidal process using 1-(alkylacyl) guanidines | GAF CORPORATION (US) | 1981-02-17 | — | — | US | disclosed |
| US-4238220-A | PLANT GROWTH REGULATORS; SEEDICIDES | ROHM AND HAAS COMPANY (US) | 1980-12-09 | — | — | US | disclosed |