Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MARS2 | Q96GW9 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8370027 | 1.00 | LMNA (0.35) | LMNATSHRDAOCYP2C19TP53 | |
| SCHEMBL8954422 | 0.90 | DAO (0.39) | LMNATSHRDAOCYP2C19SMN1; SMN2 | |
| SCHEMBL8896392 | 0.87 | LMNA (0.48) | LMNATSHRDAOCYP2C19SMN1; SMN2 | |
| SCHEMBL8370102 | 0.87 | LMNA (0.48) | LMNATSHRDAOCYP2C19SMN1; SMN2 | |
| SCHEMBL8589514 | 0.83 | TACR1 (0.34) | DAOMAPK1CTSDBACE1TACR1 | |
| SCHEMBL8589511 | 0.83 | TACR1 (0.34) | DAOMAPK1CTSDBACE1TACR1 | |
| SCHEMBL9152416 | 0.82 | TACR1 (0.35) | DAOCTSDBACE1TACR1GAA | |
| SCHEMBL8367398 | 0.81 | HTT (0.40) | LMNAMAPTSMN1; SMN2ALDH1A1CTRB1 | |
| SCHEMBL9152047 | 0.80 | TACR1 (0.32) | LMNADAOCYP2C19TP53CYP1A2 | |
| SCHEMBL9151611 | 0.80 | TACR1 (0.32) | LMNADAOCYP2C19TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401852-A | Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers | ZAMBON GROUP S.P.A. (IT) | 1995-03-28 | — | — | US | disclosed |
| EP-0423705-B1 | Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers | ZAMBON SPA (IT) | 1995-01-11 | — | — | EP | disclosed |
| US-5284966-A | Intermediates for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers | ZAMBON GROUP S.P.A. (IT) | 1994-02-08 | — | — | US | disclosed |
| US-5202484-A | PROCESS FOR THE STEREOCHEMICAL INVERSION OF (2S,3S)-2-AMINO-3-PHENYL-1,3-PROPANEDIOLS INTO THEIR (2R,3R) ENANTIOMERS | ZAMBON GROUP S.P.A. (IT) | 1993-04-13 | — | — | US | disclosed |
| EP-0423705-A2 | Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers | ZAMBON GROUP S.p.A. (IT) | 1991-04-24 | — | — | EP | disclosed |