SCHEMBL9153583

SCHEMBL9153583

COc1ccc(-c2nc(-c3cc(Br)c(O)c(OC)c3)[nH]c2-c2ccc(OC)cc2)cc1

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMPD3 Q9NY59 6/20 0.84
MAPT P10636 8/20 0.68
TP53 P04637 4/20 0.68
NOX1 Q9Y5S8 3/20 0.66
THRB P10828 1/20 0.60
MEN1 O00255 5/20 0.54
KMT2A Q03164 5/20 0.54
ALDH1A1 P00352 4/20 0.54
HPGD P15428 4/20 0.54
KDM4E B2RXH2 3/20 0.54
LMNA P02545 2/20 0.54
HTT P42858 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
MAPK13 O15264 2/20 0.52
MAPK12 P53778 2/20 0.52
MAPK11 Q15759 2/20 0.52
MAPK14 Q16539 2/20 0.52
GAA P10253 2/20 0.52
NPSR1 Q6W5P4 2/20 0.52
RAF1 P04049 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6691401 0.91 SMPD3 (1.00) SMPD3MAPTTP53NOX1MEN1
SCHEMBL11613918 0.87 MAPT (0.64) SMPD3MAPTTP53NOX1THRB
SCHEMBL6465442 0.83 NOX1 (0.81) SMPD3MAPTTP53NOX1THRB
SCHEMBL22301647 0.81 SMPD3 (1.00) SMPD3MAPTTP53NOX1THRB
SCHEMBL11595659 0.81 SMPD3 (0.76) SMPD3MAPTTP53NOX1MEN1
SCHEMBL6465425 0.81 SMPD3 (0.76) SMPD3MAPTTP53NOX1THRB
SCHEMBL12601823 0.80 SMPD3 (0.79) SMPD3MAPTTP53NOX1THRB
SCHEMBL12958682 0.80 SMPD3 (1.00) SMPD3MAPTTP53NOX1THRB
SCHEMBL8008805 0.79 NOX1 (0.85) SMPD3MAPTTP53NOX1MEN1
SCHEMBL15400824 0.79 NOX1 (0.85) SMPD3MAPTTP53NOX1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0347139-A2 Imidazole leuco dye composition containing 4'-hydroxyacetanilide diagnostic kit and method using same EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1989-12-20 EP claimed
US-4089747-A OXIDATION OF DYE-PROVIDING MATERIALS, A SULFONYL HYDRAZONE AND A COUPLER OR A TRIARYLIMIDAZOLE EASTMAN KODAK COMPANY (US) 1978-05-16 US claimed
EP-0431682-B1 Buffered wash composition, insolubilizing composition, test kits and method of use EASTMAN KODAK CO (US) 1995-02-01 EP disclosed
EP-0308236-B1 Dye-providing composition, diagnostic test kit and their use in method for ligand determination using peroxidase labeled-receptor EASTMAN KODAK CO (US) 1994-11-23 EP disclosed
US-5366864-A Buffered wash composition, insolubilizing composition, test kits and method of use EASTMAN KODAK COMPANY (US) 1994-11-22 US disclosed
US-5176999-A BUFFERED WASH COMPOSITION, INSOLUBILIZING COMPOSITION, TEST KITS AND METHOD OF USE EASTMAN KODAK COMPANY (US) 1993-01-05 US disclosed
US-5047318-A Detection Of Grampositive Bacteria EASTMAN KODAK COMPANY (US) 1991-09-10 US disclosed
US-5024935-A Determination of human chorionic gonadotropin EASTMAN KODAK COMPANY (US) 1991-06-18 US disclosed
EP-0431682-A2 Buffered wash composition, insolubilizing composition, test kits and method of use Johnson & Johnson Clinical Diagnostics, Inc. (US) 1991-06-12 EP disclosed
EP-0308236-A2 Dye-providing composition, diagnostic test kit and their use in method for ligand determination using peroxidase labeled-receptor Johnson & Johnson Clinical Diagnostics, Inc. (US) 1989-03-22 EP disclosed
US-4381921-A LATTICE STRUCTURE CONTAINING MANY VOIDS EASTMAN KODAK COMPANY (US) 1983-05-03 US disclosed
EP-0013156-A1 Particulate structure and element for analysis or transport of a liquid and method of making said element EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1980-07-09 EP disclosed